【発明の名称】α-シヌクレイン超突然変異体はα-シヌクレイン凝集を促進する

Title:

【発明の名称】α-シヌクレイン超突然変異体はα-シヌクレイン凝集を促進する

Document Type and Number:

Japanese Patent JP2002525114

Kind Code:

A

Abstract:

Parkinson's disease (PD) is a neurodegenerative disorder which is pathologically characterized by the presence of intracytoplasmic Lewy bodies, the major component of which are filaments consisting of alpha-synuclein. The present invention provides alpha-synuclein mutations which accelerate alpha-synuclein aggregation and can thus be utilized for transgenic animal production and generation of the first progressive PD model. Also provided is an in vitro aggregation assay which can be utilized to identify alpha-synuclein nucleation inhibitors for the treatment of PD.

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Inventors:

Biele, Anya Leona
Citron, Martain

Application Number:

JP2000572364A

Publication Date:

August 13, 2002

Filing Date:

September 27, 1999

Export Citation:

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Assignee:

Amjien Incorporated

International Classes:

A01K67/027; A61K45/00; A61P25/16; A61P43/00; C07K14/47; C12N15/09; C12N15/12; G01N33/15; G01N33/50; G01N33/566; G01N37/00; A61K38/00; (IPC1-7): C12N15/09; A01K67/027; A61K45/00; A61P25/16; A61P43/00; C07K14/47; G01N33/15; G01N33/50; G01N33/566; G01N37/00

Attorney, Agent or Firm:

Yoshio Kawaguchi (4 outside)

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