Title:
【発明の名称】ヘリコバクターにより惹起された疾病を処置するための置換アゾロン誘導体
Document Type and Number:
Japanese Patent JPH08506821
Kind Code:
A
Abstract:
PCT No. PCT/EP94/00380 Sec. 371 Date Jul. 18, 1995 Sec. 102(e) Date Jul. 18, 1995 PCT Filed Feb. 9, 1994 PCT Pub. No. WO94/18978 PCT Pub. Date Sep. 1, 1994The use for the manufacture of a medicament for treating Helicobacter-related diseases of a compound of formula (I) a pharmaceutically acceptable acid addition salt or a stereochemically isomeric form thereof, wherein X and Y each independently are CH or N; R1, R2 and R3 each independently are hydrogen or C1-4alkyl; R4 and R5 each independently are hydrogen, halo, C1-4alkyl, C1-4alkyloxy, hydroxy, trifluoromethyl, trifluoromethyloxy or difluoromethyloxy; Z is C=O or CHOH; and Ar is phenyl optionally substituted with up to three substituents selected from hydroxy, C1-4alkyl, C1-4alkyloxy, halo, trifluoromethyl, triC1-4alkylsilyloxy, nitro, amino and cyano or pyridinyl substituted with hydroxy or C1-4alkyloxy; and -A- is a radical of formula (a-1) (a-2) (a-3) (a-4) (a-5) (a-6) or (a-7)
Inventors:
Jerez, Jiang
Mostmans, Joseph Hector
Van der Aiken, Liyuk Alphonse Leo
Otsuz, Frank Christopher
Stoke Brex, Raymond Antoine
Van der Ar, Marcel Giosef Maria
Mostmans, Joseph Hector
Van der Aiken, Liyuk Alphonse Leo
Otsuz, Frank Christopher
Stoke Brex, Raymond Antoine
Van der Ar, Marcel Giosef Maria
Application Number:
JP51861394A
Publication Date:
July 23, 1996
Filing Date:
February 09, 1994
Export Citation:
Assignee:
Jiansen Pharmacy Yutika Naumrose Fuennaught Sheep
International Classes:
A61K31/41; A61K31/445; A61K31/4523; A61K31/495; A61K31/496; A61K31/50; A61K31/505; A61K31/695; A61P31/04; C07D233/70; C07D249/12; C07D401/04; C07D401/12; C07D401/14; C07D403/04; C07D403/12; C07F7/18; (IPC1-7): C07D233/70; A61K31/41; A61K31/695; C07D249/12; C07D401/04; C07D401/12; C07D401/14; C07D403/04; C07F7/18
Attorney, Agent or Firm:
Heiyoshi Odashima