Title:
【発明の名称】シクロオキシゲナーゼ及び5-リポキシゲナーゼを阻害するヒドロキサム酸誘導体
Document Type and Number:
Japanese Patent JPH08509487
Kind Code:
A
Abstract:
The present invention is concerned with novel hydroxamic acid derivatives of formula (I) and their use in medical therapy, particularly in the prophylaxis or treatment of clinical conditions for which an inhibitor of the lipoxygenase or cyclooxygenase mediated arachidonic acid metabolic pathway is indicated. The invention also relates to pharmaceutical formulations and processes for the preparation of compounds according to the invention. In formula (I) Y is -C(Q)=C(Q')-((E)- or (Z)-) wherein Q and Q' are independently selected from hydrogen, C1-4 alkyl and halo, or Y is -CC-; R is C1-4 alkyl optionally substituted by fluoro; D is C1-4 alkyl, phenyl or -NR<1>R<2> (wherein R<1> and R<2> are independently selected from hydrogen, C1-4 alkyl, and phenyl); and ring A and ring B are each optionally substituted by a group or groups independently selected from halo, cyano, nitro, hydroxy, C1-4 alkyl, C1-4 alkoxy, C1-4 haloalkyl, C1-4 haloalkoxy, -C(O)OR<3>, -C(O)R<3>, -C(O)NR<3>R<4>, -NR<3>R<4>, -NHCOR<3>, -NHCO2R<3>, -NHC(O)NR<3>R<4>, -NHSO2R<3>, -SO2NR<3>R<4> (wherein R<3> and R<4> are independently selected from hydrogen, C1-4 alkyl and phenyl), and -S(O)nR<5> (wherein n is an integer of from 0 to 2 and R<5> is C1-4 alkyl, C6-10 aryl (for example, phenyl or naphthyl), or C8-12 aralkyl).
Inventors:
Hodgson, Simon Teenby
Weights, Peter John
Weights, Peter John
Application Number:
JP52401894A
Publication Date:
October 08, 1996
Filing Date:
April 26, 1994
Export Citation:
Assignee:
The Welcome Foundation Limited
International Classes:
A61K31/165; A61K31/17; A61K31/195; A61K31/215; A61K31/235; A61K31/275; A61P1/00; A61P1/04; A61P3/06; A61P11/00; A61P29/00; A61P43/00; C07C259/06; C07C275/64; C07C311/16; C07C317/40; C07C323/40; (IPC1-7): C07C259/06; A61K31/165; A61K31/17; A61K31/195; A61K31/215; A61K31/235; A61K31/275; C07C275/64; C07C311/16; C07C317/40; C07C323/40
Attorney, Agent or Firm:
Takehiko Suzue (3 outside)