Title:
【発明の名称】シグマレセプターリガンド及びその用途
Document Type and Number:
Japanese Patent JPH05503517
Kind Code:
A
Abstract:
The invention relates to methods for the treatment of central nervous system disorders, gastrointestinal disorders, drug abuse, angina, migraine, hypertension and depression by administering a pharmaceutical composition comprising an effective amount of certain sigma receptor ligands to a patient in need of such treatment. The invention further relates to novel sigma receptor ligands having high binding to the sigma receptor and pharmaceutical compositions thereof. Unexpectedly, certain of the sigma receptor ligands of the present invention have selectivity for the sigma receptor over the DA, PCP and 5-HT1A receptors.
Inventors:
Glenon, Richard A.
Application Number:
JP50293591A
Publication Date:
June 10, 1993
Filing Date:
December 28, 1990
Export Citation:
Assignee:
Virginia Commonwealth University
International Classes:
A61K31/13; A61K31/135; A61K31/16; A61K31/18; A61K31/19; A61K31/215; A61K31/275; A61K31/40; A61K31/403; A61K31/4035; A61K31/435; A61K31/44; A61K31/445; A61K31/4465; A61K31/451; A61K31/495; A61K31/505; A61K31/535; A61K31/5375; A61K31/55; C07C211/08; C07C211/17; C07C211/27; C07C211/28; C07C211/29; C07C211/30; C07C211/42; C07C215/52; C07C217/16; C07C217/60; C07C219/10; C07C219/12; C07C225/16; C07C229/38; C07C233/04; C07C255/58; C07C317/32; C07C323/32; C07D207/12; C07D209/48; C07D211/14; C07D211/36; C07D211/46; C07D211/52; C07D211/70; C07D223/16; C07D239/42; C07D265/30; C07D295/02; C07D295/03; C07D295/033; C07D295/06; C07D295/073; C07D295/096; C07D295/108; C07D295/192; C07D317/58; C07D471/08; (IPC1-7): A61K31/13; A61K31/16; A61K31/18; A61K31/19; A61K31/275; A61K31/40; A61K31/445; A61K31/535; C07/; C07C211/27; C07C211/28; C07C211/29; C07C211/30; C07C215/52; C07C217/16; C07C217/60; C07C225/16; C07C229/38; C07C233/04; C07C255/58; C07C317/32; C07C323/32; C07D209/48; C07D211/14; C07D211/36; C07D211/70; C07D265/30
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)