Title:
【発明の名称】ジヒドロピリジンソフトドラッグならびに関連する組成物及び方法
Document Type and Number:
Japanese Patent JP2003535096
Kind Code:
A
Abstract:
This invention relates to novel dihydropyridine soft drugs of the formula PhiOOR1, where Phi is a dihydropyridine moiety. These compounds are useful as calcium channel antagonists with cardiovascular, antiasthmatic and antibroncho-constriction activity. Use of such soft drug analogs permits the administration of greater doses of the claimed dihydropyridine compounds without intolerable systemic effects. Thus, this invention also provides pharmaceutical compositions, as well as methods, for preventing and treating disorders such as hypersensitivity, allergy, asthma, bronchospasm, dysmenorrhea, esophageal spasm, glaucoma, premature labor, urinary tract disorders, gastrointestinal motility disorders and cardiovascular disorders, while avoiding unwanted systemic effects.
Inventors:
Dotsudo, Jiyoung H
Barrington, The Ames El
Hall, Daniel A.
Henry The Ames Earl
Rupert, Kenneth See
Barrington, The Ames El
Hall, Daniel A.
Henry The Ames Earl
Rupert, Kenneth See
Application Number:
JP2002500880A
Publication Date:
November 25, 2003
Filing Date:
May 02, 2001
Export Citation:
Assignee:
Ortho-McNeill Pharmacy Incorporated
International Classes:
A61K31/443; A61K31/55; A61P1/00; A61P9/00; A61P9/02; A61P11/06; A61P11/08; A61P13/02; A61P15/00; A61P15/06; A61P27/06; A61P37/08; A61P43/00; C07D211/90; C07D495/04; C07D497/04; C07D405/12; (IPC1-7): C07D405/12; A61K31/443; A61K31/55; A61P1/00; A61P9/00; A61P9/02; A61P11/06; A61P11/08; A61P13/02; A61P15/00; A61P15/06; A61P27/06; A61P37/08; A61P43/00; C07D495/04; C07D497/04
Attorney, Agent or Firm:
Heiyoshi Odashima