Title:
【発明の名称】最小限の全身吸収を与える局所用の抗炎症剤組成物
Document Type and Number:
Japanese Patent JPH05501871
Kind Code:
A
Abstract:
Topical polyethylene glycol based formulations for the delivery of 2-substituted-1-naphthols and indoles and particularly, 2-phenylmethyl-1-naphthol are provided. Said topical formulations exert excellent localized antiinflammatory activity while demonstrating low levels of skin penetration in vitro and in vivo thereby reducing unwanted side effects and reducing systemic toxicity associated with the active drug compounds.
Inventors:
Angst, Bruce Jeffrey
Application Number:
JP51225190A
Publication Date:
April 08, 1993
Filing Date:
August 20, 1990
Export Citation:
Assignee:
The DuPont Merck Pharmaceuticals Company
International Classes:
A61K9/06; A61K9/00; A61K31/015; A61K31/05; A61K31/085; A61K31/135; A61K31/165; A61K31/18; A61K31/19; A61K31/22; A61K31/40; A61K31/66; A61K31/665; A61K31/67; A61K31/675; A61K47/10; A61K47/34; A61P29/00; C07C39/14; C07C39/38; C07C43/253; C07C49/835; C07C49/84; C07C65/17; C07C69/157; C07C69/732; C07C69/734; C07C69/738; C07C69/94; C07C229/40; C07C233/23; C07C235/40; C07C247/02; C07C255/01; C07C311/07; C07C317/20; C07C323/17; C07F9/40; C07F9/572; (IPC1-7): A61K9/06; A61K31/015; A61K31/05; A61K31/085; A61K31/135; A61K31/165; A61K31/18; A61K31/19; A61K31/22; A61K31/40; A61K31/66; A61K31/665; A61K31/67; A61K31/675; A61K47/34; C07; C07C39/14; C07C39/38; C07C43/253; C07C65/17; C07C69/157; C07C69/734; C07C69/738; C07C69/94; C07C229/40; C07C233/23; C07C235/40; C07C255/01
Attorney, Agent or Firm:
Chika Takagi (2 outside)