Title:
【発明の名称】耳毒性薬、騒音および放射線の毒性を軽減するためのD-メチオニンの使用
Document Type and Number:
Japanese Patent JP2001518499
Kind Code:
A
Abstract:
Methods of preventing or reducing hearing or balance loss, damage to ear cells, weight loss, gastrointestinal toxicity, neurotoxicity, alopecia, and prolonging survival in patients undergoing treatment with therapeutically effective amounts of platinum-containing chemotherapeutic agents such as cisplatin are provided. Methods are also provided for preventing or reducing such symptoms in patients undergoing treatment with loop diuretics, aminoglycoside antibiotics, iron chelating agents, quinine, and quinidine, or those who have been exposed to toxic levels of noise or radiation. These methods comprise administering an effective amount of a methionine protective agent, such as D-methionine, prior to, simultaneously with, or subsequently to administration of the platinum-containing chemotherapeutic agent, loop diuretic agent, etc., or exposure to noise or radiation. Combinations of these time periods can also be employed.
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Inventors:
Kathleen C. M. Campbell
Application Number:
JP2000514636A
Publication Date:
October 16, 2001
Filing Date:
April 08, 1998
Export Citation:
Assignee:
SOUTHERN ILLINOIS UNIVERSITY
International Classes:
A61K31/10; A61K31/145; A61K31/198; A61K31/28; A61K31/49; A61K31/7076; A61K33/243; A61K45/00; A61K45/06; A61P1/04; A61P17/14; A61P43/00; (IPC1-7): A61K45/00; A61K31/10; A61K31/198; A61K31/7076; A61P1/04; A61P17/14; A61P43/00
Attorney, Agent or Firm:
Aoyama Ryo (2 outside people)