Title:
【発明の名称】ベンズイミダゾール化合物、およびGABAAレセプター複合体のモジュレーターとしてのその使用
Document Type and Number:
Japanese Patent JP3171852
Kind Code:
B2
Abstract:
PCT No. PCT/EP96/01649 Sec. 371 Date Dec. 23, 1997 Sec. 102(e) Date Dec. 23, 1997 PCT Filed Apr. 19, 1996 PCT Pub. No. WO96/33191 PCT Pub. Date Oct. 24, 1996The present patent application discloses compounds having the formula or a pharmaceutically acceptable salt thereof or an oxide thereof wherein R3 is wherein A, B and D each is CH, or one or two of A, B and D is N and the others are CH; R11 is phenyl, benzimidazolyl, or monocyclic heteroaryl, all of which may be substituted one or more times with substituents selected from alkyl, alkoxy, halogen, CF3, amino, nitro, cyano, acylamino, acyl, phenyl and monocyclic heteroaryl; one of R6 and R7 is hydrogen and the other is -CR'=NOR'', wherein R' and R'' each independently are hydrogen, alkyl, alkenyl, alkynyl or phenyl. The compounds are useful for the treartment of various central nervous system disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders.
Inventors:
Tuver, Reine
Frank Bethien
Yoshimasa Fukuda
Osamu Ushiroda
Etsuro Sasaki
Frank Bethien
Yoshimasa Fukuda
Osamu Ushiroda
Etsuro Sasaki
Application Number:
JP53148496A
Publication Date:
June 04, 2001
Filing Date:
April 19, 1996
Export Citation:
Assignee:
NEUROSEARCH A/S
International Classes:
A61K31/00; A61K31/415; A61K31/4164; A61K31/4184; A61K31/425; C07D401/14; A61K31/427; A61K31/44; A61K31/4427; A61K31/443; A61K31/4433; A61K31/4439; A61K31/501; A61K31/505; A61K31/506; A61P25/00; A61P25/04; A61P25/08; A61P25/20; A61P25/22; A61P25/28; A61P43/00; C07D235/06; C07D401/10; C07D403/10; C07D403/14; C07D405/10; C07D405/14; C07D409/10; C07D413/14; C07D417/10; C07D417/14; C07D521/00; (IPC1-7): C07D401/10; A61K31/4184; A61P25/00; C07D403/10
Domestic Patent References:
| JP72838A |
Attorney, Agent or Firm:
Kenji Yoshitake (3 others)