Title:
【発明の名称】モノまたはジケトン二環式化合物の誘導体の使用、それにより得られた化合物、並びに炎症、片頭痛およびショックの治療用薬剤としてのそれらの用途
Document Type and Number:
Japanese Patent JP2000502334
Kind Code:
A
Abstract:
The therapeutical use of bicyclic derivatives and pharmaceutically acceptable salts thereof having general formula (I), wherein each of X1, X2, X3 and X4 is independently a carbon atom or a nitrogen atom, with n being 0 or 1; A is selected from an oxygen atom and a carbonyl grouping; each of R1 and R2 is independently either: a hydrogen atom; or an optionally substituted aromatic ring or an optionally substituted heteroaromatic ring having one or more heteroatoms, a saturated ring optionally having one or more heteroatoms, optionally substituted by an alkyl chain; or a chain having 1-4 atoms, consisting of optionally substituted nitrogen, a carbonyl grouping optionally terminated with an optionally substituted aromatic ring or an optionally substituted heteroaromatic ring optionally having one or more heteroatoms; R3 is a hydrogen atom, a halogen atom, a C1-5 alkyl radical, a nitrogen radical substituted by two groupings that are each independently a hydrogen atom or a C1-5 alkyl grouping optionally incorporating a carbonyl grouping, or an aromatic ring; and R4 is a hydrogen atom, a halogen atom, a C1-5 alkyl radical, or an optionally substituted oxygen-containing derivative, with the exception of 6-phenylamino-5,8-quinolinedione and 2-N-acetylamino-1,4-naphthoquinone.
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Inventors:
Buzalin-Falson, Oder
Desk Wand-Billiard, Stephanie
Fabro, Anita
Finnet, michel
Tembo, Olivier
Tolgrossa, Jean Luka
Yannick-Arnaud, Silvie
Desk Wand-Billiard, Stephanie
Fabro, Anita
Finnet, michel
Tembo, Olivier
Tolgrossa, Jean Luka
Yannick-Arnaud, Silvie
Application Number:
JP52179897A
Publication Date:
February 29, 2000
Filing Date:
December 10, 1996
Export Citation:
Assignee:
Laboratore Inotera Society Anonym
International Classes:
C07D295/08; A61K31/00; A61K31/135; A61K31/136; A61K31/165; A61K31/167; A61K31/17; A61K31/35; A61K31/352; A61K31/357; A61K31/36; A61K31/40; A61K31/403; A61K31/404; A61K31/47; A61K31/472; A61K31/495; A61K31/4965; A61K31/535; A61K31/5375; A61P9/00; A61P9/14; A61P17/00; A61P19/00; A61P19/02; A61P25/06; A61P29/00; C07C225/30; C07C233/32; C07C243/38; C07C275/30; C07D209/08; C07D213/74; C07D213/86; C07D215/24; C07D217/02; C07D237/28; C07D237/30; C07D239/74; C07D241/42; C07D295/116; C07D311/22; C07D311/36; C07D319/20; (IPC1-7): A61K31/136; A61K31/167; A61K31/17; A61K31/352; A61K31/36; A61K31/404; A61K31/472; A61K31/4965; A61K31/5375; A61P9/14; A61P17/00; A61P19/02; A61P25/06; A61P29/00; C07C225/30; C07C243/38; C07C275/30; C07D209/08; C07D217/02; C07D295/08; C07D311/36; C07D319/20
Attorney, Agent or Firm:
Takashi Ishida (4 others)