Title:
【発明の名称】骨格筋収縮を阻害する酸化窒素種および付加物の使用
Document Type and Number:
Japanese Patent JPH10511075
Kind Code:
A
Abstract:
A method for inhibiting or relaxing skeletal muscle contractions which comprises contacting said skeletal muscle with a skeletal muscle relaxing amount, and a method for the treatment of disease states resulting from or exacerbated by undesirable contractions of skeletal muscle, which comprises administering a skeletal muscle relaxing amount to an individual in need thereof of a compound selected from the group consisting of nitroxyl ion (NO-), nitrosonium ion (NO+), nitric oxide and nitric oxide adducts or providers. This invention also is directed to stimulating the contraction of muscles in a mammal by administering an effective amount of a nitric oxide synthase inhibitor.
Inventors:
Stemmer, Jonathan
Kovtsik, Leicester
Kovtsik, Leicester
Application Number:
JP50512895A
Publication Date:
October 27, 1998
Filing Date:
July 13, 1995
Export Citation:
Assignee:
Duke University
President and Fellows of Harvard College
President and Fellows of Harvard College
International Classes:
A61K31/04; A61K31/095; A61K31/13; A61K31/16; A61K31/198; A61K31/40; A61K31/401; A61K31/403; A61K31/426; A61K31/517; A61K31/519; C07D207/16; A61K31/5415; A61K31/549; A61K31/675; A61K33/00; A61K38/00; A61K38/05; A61K38/17; A61K38/55; A61K45/00; A61P43/00; (IPC1-7): A61K33/00; A61K31/04; A61K31/095; A61K31/13; A61K31/16; A61K31/40; A61K31/675; A61K38/00; A61K45/00; C07D207/16
Attorney, Agent or Firm:
Hiroyuki Niwa