Title:
【発明の名称】勃起障害症状改善のために、刺激物質の活性成分としてプロアントシアニジン、一酸化窒素源としてLアルギニン又はその塩の使用
Document Type and Number:
Japanese Patent JP2003534286
Kind Code:
A
Abstract:
Use of proanthocyanidins as an active ingredient of a stimulator and L-arginine or its salts as a source of nitric oxide in the treatment of erectile dysfunction. The active ingredient stimulates the endothelial NO-synthase enzyme, which acts as a catalyst for the synthesis of nitric oxide from its substrate L-arginine or its salts. The nitric oxide in turn activates the guanylyl cyclase, which leads to an increased development of cyclic guanosine monophosphate, which causes relaxation of smooth muscles. Blood vessel diameter may increase. The stimulator may also have Sildenafil or enzymes that inhibit an enzyme phosphodiesterase type from reducing an amount of the cyclic guanosine monophosphate.
Inventors:
Peter Rodwald
Ferrari, Victor
Ferrari, Victor
Application Number:
JP2001585787A
Publication Date:
November 18, 2003
Filing Date:
May 24, 2001
Export Citation:
Assignee:
Hofer Research Limited
International Classes:
A61K31/765; A61K31/195; A61K31/198; A61K31/353; A61K31/519; A61K31/7048; A61K36/15; A61K39/385; A61P9/08; A61P15/10; A61P21/02; A61P43/00; (IPC1-7): A61K31/765; A61K31/198; A61K31/353; A61K31/519; A61P9/08; A61P15/10; A61P21/02; A61P43/00
Foreign References:
| DE19845314A1 | 2000-04-06 | |||
| WO1999045797A1 | 1999-09-16 | |||
| WO1999001132A1 | 1999-01-14 | |||
| WO1999027905A1 | 1999-06-10 |
Attorney, Agent or Firm:
Toshiyuki Maruyama (3 others)