Title:
【発明の名称】大腸ポリープを治療するためのチロシンキナーゼインヒビターとしてのキナゾリン誘導体の使用
Document Type and Number:
Japanese Patent JP2001522802
Kind Code:
A
Abstract:
This invention provides a method of treating or inhibiting colonic polyps in a mammal in need thereof which comprises administering to said mammal a compound having formula (I), wherein X is phenyl which is optionally substituted; R and R1 are each independently, hydrogen, halogen, alkyl, alkoxy, hydroxy or trifluoromethyl; R2 is hydrogen, alkyl, alkoxy, hydroxy or trifluoromethyl; Y is a radical selected from the group consisting of formulae (II), (III), (IV), (V), (VI), (VII) and (VIII). R3 is independently hydrogen, alkyl, carboxy, carboalkoxy, phenyl, or carboalkyl; n = 2-4; or a pharmaceutically acceptable salt thereof, with the proviso that each R3 of Y may be the same or different.
Inventors:
Philip Frost
Application Number:
JP2000520129A
Publication Date:
November 20, 2001
Filing Date:
November 04, 1998
Export Citation:
Assignee:
American Cyanamid Company
International Classes:
A61K31/505; A61K31/517; A61P1/00; A61P43/00; C07D239/94; (IPC1-7): A61K31/517; A61P1/00; A61P43/00
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)