Title:
【発明の名称】アミノアルギニンの分離および身体内の酸化窒素生成を遮断するための用途
Document Type and Number:
Japanese Patent JP2728148
Kind Code:
B2
Abstract:
Pharmaceutically pure physiologically active N-aminoarginine (i.e., the L or D,L form) or pharmaceutically acceptable salt thereof is administered in a nitric oxide synthesis inhibiting amount to a subject in need of such inhibition (e.g. a subject with low blood pressure or needing immunosuppressive effect) or is added to a medium containing isolated organs, intact cells, cell homogenates or tissue homogenates in an amount sufficient to inhibit nitric oxide formation to elucide or control the biosynthesis, metabolism or physiological role of nitric oxide. N-amino-L-arginine is prepared and isolated as a pharmaceutically pure compound by reducing N-nitro-L-arginine, converting L-arginine by-product to L-ornithine with arginase and separating N-amino-L-arginine from the L-ornithine. N-amino-D,L-arginine is prepared in similar fashion starting with N-nitro-D,L-arginine.
Inventors:
GURIFUISU OOEN TABURYU
Application Number:
JP51061890A
Publication Date:
March 18, 1998
Filing Date:
July 30, 1990
Export Citation:
Assignee:
KOONERU RISAACHI FUAUNDEESHON INC
International Classes:
A61K31/195; A61K31/198; A61P9/00; A61P9/02; A61P11/00; A61P13/02; A61P15/00; A61P37/06; A61P43/00; C07C277/08; C07C281/16; (IPC1-7): C07C281/16; A61K31/195
Domestic Patent References:
| JP2513075A |
Other References:
【文献】Acta Chimica Academiae Scientiarm Hungaricae,Tomus 第85巻第3号,第327~332頁 (1975)
【文献】Biochemical And Biophysical Research Communications 第160巻第2号,第881~886頁 (1989)
【文献】Biochemical And Biophysical Research Communications 第160巻第2号,第881~886頁 (1989)
Attorney, Agent or Firm:
Aoyama Ryo (1 person outside)