Title:
【発明の名称】バニロイド類の単純ヘルペス感染症の治療のための使用
Document Type and Number:
Japanese Patent JP2874896
Kind Code:
B2
Abstract:
The present invention provides methods of treating or preventing herpes simplex infections in humans and lower animals by treatment with natural and synthetic vanilloid compounds, and the pharmaceutically-acceptable salts and amides thereof, having the general structure: n = 0 or 1; the -W-X- moiety is selected from -C(O)NH-, -C(S)NH-, -S(0)2NH-, -NHC(O)O-, -NHC(S)O-, -NHC(O)NH-, -NHC(S)NH-, -C(O)O-, -C(O)S- and -C(O)N(R)-, wherein either available bond of the -W-X-moiety may be bonded to the -R moiety, with the other bond being attached to the benzyl carbon atom, or directly attached to the benzene ring; the -R<1> moiety is selected from hydrogen, hydroxy, alkyl esters of hydroxy having from about 1 to about 5 carbon atoms, alkyl having from about 1 to about 5 carbon atoms, and alkoxy having from about 1 to about 5 carbon atoms; the -Z moiety is selected from hydrogen, hydroxy and methoxy; the -Y- moiety is selected from -O-, -S-, -NH-, -OC(O)-, -OSO3=- and -OPO3=-; the -V moiety is selected from hydrogen, short chain alkyl, and -CR<2>2-CR<2>2-NH2; the -R<2> moieties are each independently selected from hydrogen, halogen, unsubstituted or substituted alkyl having from about 1 to about 6 carbon atoms, substituted or unsubstituted aryl, and carboxylate, or two -R<2> moieties are covalently bonded to form a substituted or unsubstituted alkyl or heteroalkyl ring having from about 3 to about 8 atoms in the ring including from 0 to about 3 heteroatoms; and the -R moiety is a C2-C24 alkyl moiety which may be straight, branched or cyclic chain and may be saturated, monounsaturated, or polyunsaturated, substituted or unsubstituted, or two -R moieties are covalently bonded to form a substituted or unsubstituted alkyl ring having from about 2 to about 14 carbon atoms in the ring.
Inventors:
CHIMOSHII PIITAA ONIIRU
JERARUDO BURUUSU KASUTEINGU
TOOMASU RII KATSUPUSU
JERARUDO BURUUSU KASUTEINGU
TOOMASU RII KATSUPUSU
Application Number:
JP15556689A
Publication Date:
March 24, 1999
Filing Date:
June 17, 1989
Export Citation:
Assignee:
PUROKUTAA ANDO GYANBURU CO ZA
International Classes:
A61K31/00; A61K31/16; A61K31/165; A61K31/18; A61K31/265; A61K31/27; C07D209/48; A61K31/33; A61K31/66; A61P31/12; A61P31/22; C07C233/20; C07D521/00; (IPC1-7): A61K31/165; A61K31/18; A61K31/265; A61K31/27; A61K31/33; A61K31/66
Domestic Patent References:
| JP60208913A | ||||
| JP60214733A | ||||
| JP6248657A |
Other References:
Ｊｏｕｒｎａｌ ｏｆ Ｎｅｕｒｏｌｏｇｉｃａｌ Ｓｃｉｅｎｃｅｓ，Ｖｏｌ．７２，Ｎｏ．２−３（１９８６）ｐ．２２３−２３０
Attorney, Agent or Firm:
Kazuo Sato (2 outside)