Title:
塩酸イコチニブ、合成物、結晶学的形態、併用薬及びその用途
Document Type and Number:
Japanese Patent JP5719770
Kind Code:
B2
Abstract:
The invention relates to 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, its therapeutic usage for treatment of diseases mediated by EGFR kinase and its combinatory therapeutic usage together with other therapeutic agents. The invention also provides synthetic methods for preparation of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride, its new crystalline forms, and the relevant synthetic intermediates for synthesis of 4-[(3-ethynylphenyl)amino]-6,7-benzo-12-crown-quinazoline hydrochloride.
More Like This:
Inventors:
King Insho
Guotian Xie
Politeness
Tan Tanrai
Hu Yun Geese
What great
Charles Davis
Don Chan
I Haima
Korea
Ryu Wei
Liu Yu
Guotian Xie
Politeness
Tan Tanrai
Hu Yun Geese
What great
Charles Davis
Don Chan
I Haima
Korea
Ryu Wei
Liu Yu
Application Number:
JP2011516948A
Publication Date:
May 20, 2015
Filing Date:
July 07, 2009
Export Citation:
Assignee:
BETA PHARMA, INC.
International Classes:
C07D491/056; C07D323/00
Domestic Patent References:
| JP2002338577A |
Foreign References:
| WO2003082830A1 |
Other References:
RAPID COMMUNICATIONS IN MASS SPECTROMETRY,2008年,Vol.22,p.2176-2184
新医薬品の規格及び試験方法の設定について,医薬審発568号,2001年
Journal of Polymer Science, Part A: Polymer Chemistry,2006年,Vol.44, No.7,p.2270-2281
Inorganic Chemistry,1990年,Vol.29, No.14,p.2599-2607
新医薬品の規格及び試験方法の設定について,医薬審発568号,2001年
Journal of Polymer Science, Part A: Polymer Chemistry,2006年,Vol.44, No.7,p.2270-2281
Inorganic Chemistry,1990年,Vol.29, No.14,p.2599-2607
Attorney, Agent or Firm:
Samejima Mutsumi
Kyousei Tamura
Masahiro Nitta
Kure Hidenori
Kyousei Tamura
Masahiro Nitta
Kure Hidenori