IDENTIFICATION OF COMPOUND REGULATING ACTIVITY OF TRANSCRIPTION FACTOR, NF-IL6/LAP

Japanese Patent JP3162683

B2

PROBLEM TO BE SOLVED: To identify a compound which regulates or activates the gene expression activity of the subject transcription factor by affecting the phosphorylation state of a specific amino acid residue in nuclear factor-interleukin 6/lymphokine activation protein.
SOLUTION: This is a method for identifying a compound which regulates the activity of nuclear factor-interleukin 6/lymphokine activation protein (NF- IL6/LAP) by affecting the phosphorylation state of an amino acid residue 105 in the NF-IL6/LAP. In view of the fact that the component containing this compound and NF-IL6/LAP is incubated under the sufficient condition for mutually reacting them and, as a result, the action of this compound on the phosphorylation state of NF-IL6/LAP is shown by the difference in the phosphorylation state of the amino acid residue 105, i.e., the compound regulating the activity of NF-IL6/LAP is identified by comparing the phosphorylation state of this residue before and after the incubation.

Karin, Michael
Trout vine, christian

JP16254799A

May 08, 2001

July 20, 1994

Click for automatic bibliography generation  

The Regents of the University of California

G01N33/53; A61K31/00; A61K31/70; A61K38/00; A61K39/395; A61K48/00; A61P35/00; A61P37/00; A61P37/02; A61P43/00; C07H21/04; C07K14/47; C07K16/18; C12N5/10; C12N15/00; C12N15/02; C12N15/09; C12N15/12; C12P21/08; G01N33/15; G01N33/50; C12R1/91; (IPC1-7): G01N33/15; A61K38/00; C12N15/09; G01N33/50

Ｇｅｎｅｓ Ｄｅｖ．，４（１９９０）ｐ．１５４１−１５５１
Ｊ．Ｂｉｏｌ．Ｃｈｅｍ．，２６７（１９９２）ｐ．１９３９６−１９４０３
Ｐｒｏｃ．Ｎａｔｌ．Ａｃａｄ．Ｓｃｉ．ＵＳＡ，８９（１９９２）ｐ．１４７３−１４７６
Ｐｒｏｃ．Ｎａｔｌ．Ａｃａｄ．Ｓｃｉ．ＵＳＡ，９０（１９９３）ｐ．２２０７−２２１１

Atsushi Nakajima (2 outside)

Previous Patent: 防塵軸流ファン装置

Next Patent: ELECTRON-IMPACT TYPE EVAPORATION LINE SOURCE