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Title:
膜貫通型タンパク質と相互作用する化合物の同定法
Document Type and Number:
Japanese Patent JP5187910
Kind Code:
B2
Abstract:
A method for screening a candidate compound for its ability to interact with at least one transmembrane protein comprising: transfecting a cell with at least one nucleotide sequence encoding a protein comprising a transmembrane protein containing at least one nuclear localisation sequence (NLS) and a detectable moiety and permitting expression of the encoded protein in the cell; contacting the cell with a candidate compound; and determining the distribution of the expressed protein in the cell by detecting the distribution of the detectable moiety in the cell; wherein detection of an altered distribution of the detectable moiety in the cell relative to the distribution of the detectable moiety in a control cell not contacted with the candidate compound indicates that the compound interacts with the transmembrane protein, and wherein the wild type transmembrane protein contains an NLS.

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Inventors:
Ordered Brian F.
George Susan Earl.
Application Number:
JP2009267007A
Publication Date:
April 24, 2013
Filing Date:
November 25, 2009
Export Citation:
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Assignee:
Omelos Corporation
International Classes:
C12Q1/02; C07K14/705; C07K14/71; C07K14/72; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/09; C12N15/85; G01N33/15; G01N33/50; G01N33/53; G01N33/543; G01N33/566; G01N33/567; G01N33/68; G01N33/92
Foreign References:
WO2001058916A2
WO2001017532A1
Other References:
American journal of physiology. Renal physiology. 2000, Vol.279, No.3, p.F440-F448
Pharmacology & therapeutics. 2001, Vol.92, No.2-3, p.71-87
Bioessays. 2000, Vol.22, No.6, p.532-544
Attorney, Agent or Firm:
Hatsushi Shimizu
Masao Haruna
Hirotaka Yamaguchi
Toshi Gobe
Ryuichi Inoue
Toshimitsu Sato
Koichi Niimi
Tomohiko Kobayashi
Shinichi Watanabe
Masato Ozeki
Yoshihiro Igarashi
Kazuya Kawamoto



 
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