Title:
前立腺細胞中のタンパク質チロシンキナーゼおよび/またはタンパク質チロシンキナーゼ経路と相互作用しかつ/またはそれを調節する化合物の活性を予測するためのポリヌクレオチドの同定
Document Type and Number:
Japanese Patent JP2010517510
Kind Code:
A
Abstract:
The present invention describes polynucleotides that have been discovered to correlate to the relative intrinsic sensitivity or resistance of cells, e.g., prostate cell lines, to treatment with compounds that interact with and modulate, e.g., inhibit, protein tyrosine kinases, such as, for example, members of the Src family of tyrosine kinases, e.g., Src, Fgr, Fyn, Yes, Blk, Hck, Lck and Lyn, as well as other protein tyrosine kinases, including, Bcr-abl, Jak, PDGFR, c-kit and Eph receptors. These polynucleotides have been shown to have utility in predicting the resistance and sensitivity of prostate cell lines to the compounds. The expression level or phosphorylation status of some polynucleotides is regulated by treatment with a particular protein tyrosine kinase inhibitor compound, thus indicating that these polynucleotides are involved in the protein tyrosine kinase signal transduction pathway, e.g., Src tyrosine kinase. Such polynucleotides, whose expression levels correlate highly with drug sensitivity or resistance and which are modulated by treatment with the compounds, comprise polynucleotide predictor or marker sets useful in methods of predicting drug response, and as prognostic or diagnostic indicators in disease management, particularly in those disease areas, e.g., prostate cancer, in which signaling through the protein tyrosine kinase pathway, such as the Src tyrosine kinase pathway, is involved with the disease process.
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Inventors:
Juan Faye
Edwin A. Clark
One Seed
Edwin A. Clark
One Seed
Application Number:
JP2009545639A
Publication Date:
May 27, 2010
Filing Date:
January 08, 2008
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
C12Q1/68; A61K31/506; A61K45/00; A61P13/08; A61P35/00; C07K14/47; C12N15/09; C12Q1/02; C12Q1/48; G01N33/15; G01N33/50; G01N33/574; G01N37/00; C07D417/14
Domestic Patent References:
| JP2006515742A | 2006-06-08 |
Attorney, Agent or Firm:
Mitsuo Tanaka
Hiroshi Yamazaki
Michiko Matsutani
Mina Shiga
Sakurai Yoko
Satoshi Hashimoto
Hiroshi Yamazaki
Michiko Matsutani
Mina Shiga
Sakurai Yoko
Satoshi Hashimoto