IDO INHIBITORS

Japanese Patent JP2014159492

A

PROBLEM TO BE SOLVED: To provide an IDO inhibitor.SOLUTION: In various embodiments of this disclosure, a method is provided which relates to the following: (a) modulating an activity of indoleamine 2,3-dioxygenase comprising contacting an indoleamine 2,3-dioxygenase with a modulation effective amount of a compound as described in one of the aspects described herein; (b) treating indoleamine 2,3-dioxygenase (IDO) mediated immunosuppression in a subject in need thereof, comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein; (c) treating a medical conditions that is improved by inhibiting an enzymatic activity of indoleamine-2,3-dioxygenase comprising administering an effective indoleamine 2,3-dioxygenase inhibiting amount of a compound as described in one of the aspects described herein, and the like.

MARIO MAUTINO
FIROZ JAIPURI
AGNIESZKA MARCINOWICZ-FLICK
TANAY KESHARWANI
JESSE WALDO
STEVEN JAMES COLLIER

JP2014119425A

September 04, 2014

June 10, 2014

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NEWLINK GENETICS CORP

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Shusaku Yamamoto
Natsuki Morishita

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