Title:
ILEUM TYPE BILE ACID TRANSPORTER INHIBITOR
Document Type and Number:
Japanese Patent JP2000178188
Kind Code:
A
Abstract:
To obtain the subject transporter inhibitor having excellent ileum type bile acid transporter inhibiting action and useful as a treating or preventing agent for hyperlipemia and arteriosclerosis by including new benzylamines.
This transporter inhibitor comprises benzylamines of formula I [R1 is a (substituted)6-10C aryl, a (substituted)tetrazolyl or the like; R2 to R4 are each H, a 1-6C alkyl or the like; R5 is a (substituted)6-10C aryl or the like; R6 is a 1-10C alkyl, a (substituted)7-16C aralkyl or the like, e.g. N-(1- phenylethyl)-{phenyl-[6-hydroxy-4-methoxy-2-(1H-tetrazol-5-yl) phenyl]methyl}amine as an active ingredient. The compound of formula I is obtained by reacting, e.g. a compound of formula II with a compound of the formula H2N-R6 in an inert solvent to provide a compound of formula III, reducing the compound of formula III in the inert solvent and removing a preventing group for amino group of the resultant compound.
Inventors:
ISHIHARA SADAO
SAITO FUJIO
MASUKO HIDEKAZU
KOUNO KEITA
Application Number:
JP35288198A
Publication Date:
June 27, 2000
Filing Date:
December 11, 1998
International Classes:
C07D333/20; A61K31/00; A61K31/135; A61K31/137; A61K31/165; A61K31/166; A61K31/18; A61K31/185; A61K31/38; A61K31/381; A61K31/40; A61K31/403; A61K31/404; A61K31/41; A61K31/42; A61K31/421; A61K31/423; A61K31/425; A61K31/426; A61K31/428; A61P3/00; A61P3/06; A61P9/00; A61P9/10; C07C237/30; C07C237/34; C07C309/32; C07C309/42; C07C311/08; C07C311/51; C07C311/54; C07C317/34; C07D207/335; C07D209/14; C07D257/04; C07D263/32; C07D263/56; C07D277/28; C07D277/64; C07D333/48; C07D333/58; C07D403/10; C07D409/10; C07D413/10; C07D417/10; (IPC1-7): A61K31/137; A61K31/166; A61K31/18; A61K31/185; A61K31/381; A61K31/40; A61K31/404; A61K31/41; A61K31/421; A61K31/423; A61K31/426; A61K31/428; A61P3/06; A61P9/10; C07C237/30; C07C237/34; C07C309/32; C07C309/42; C07C311/08; C07C311/51; C07C311/54; C07C317/34
Attorney, Agent or Firm:
Akio Ohno (2 outside)
