Title:
抗癌剤として有用なイルジン類似体
Document Type and Number:
Japanese Patent JP4989648
Kind Code:
B2
Abstract:
Acylfulvene analogs, which inhibit tumor growth, especially solid tumor growth, and which have an adequate therapeutic index to be effective for in vivo treatment are provided herein. The compounds described herein are useful as anti-neoplastic agents, i.e., to inhibit tumor cell growth in vitro or in vivo, in mammalian hosts, such as humans or animals, e.g., domestic animals, and are effective against solid tumors, hematologic malignancies and multi-drug resistant cancers/tumors. The present compounds can be used alone or they can be used in combination with one or more anti-cancer or anti-tumor agents.
Inventors:
McMorris, Trevor See.
Kellner, Michael Jay.
Kellner, Michael Jay.
Application Number:
JP2008525225A
Publication Date:
August 01, 2012
Filing Date:
August 03, 2006
Export Citation:
Assignee:
The Regents of The University of California
International Classes:
C07C239/14; A61K31/133; A61K31/17; A61K31/27; A61P35/00; C07C271/18; C07C275/64; C07C335/40
Domestic Patent References:
| JP2000515524A | ||||
| JP2002503714A | ||||
| JP4211655A | ||||
| JP8134030A |
Foreign References:
| US5256789 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita