Title:
坑腫瘍剤として有用なイルジン類似体
Document Type and Number:
Japanese Patent JP4372843
Kind Code:
B2
Abstract:
The present invention provides illudin analogs of general formula (I) where R1 is (CH2)n -X-Y or H; n is 0 to 4; X is O or S or N or absent; and Y is an optionally substituted (C1 - C8)alkyl, (C6-C10)aryl, (C6-C10)aryl(C1-C4)alkyl or cyclo(C3-C6) alkyl optionally comprising one or more heteroatoms; a monosaccharide, an amino acid residue, or H when n is 2-4; R2 is absent; or R1 and R2 together comprise a 5-7-membered cyclic ring; R3 is (C1-C4)alkyl or H; R4 is H, SCH2CO2(C1-C4)alkyl, O-(C5-C12)aryl or -S-(C5-C12)aryl; R5 is H, OH or absent; R6 is (C1-C4)alkyl or absent; R7 is OH or OSi((C1-C4)alkyl)3; or R6 and R7 together are ethylenedioxy; R8 is optionally substituted (C1-C4)alkyl, and the bonds represented by ---- are individually present or absent. The invention further provides dimers comprising analogs of formula (I).
Inventors:
McMorris, Trevor See.
Kellner, Michael Jay.
Kellner, Michael Jay.
Application Number:
JP50700998A
Publication Date:
November 25, 2009
Filing Date:
July 14, 1997
Export Citation:
Assignee:
The Regents of The University of California
International Classes:
C07C49/757; A61K9/08; C07D233/64; A61K9/48; A61K31/122; A61K31/19; A61K31/215; A61K31/357; A61K31/36; A61K31/695; A61K31/7028; A61P35/00; C07C35/37; C07C39/17; C07C49/727; C07C49/737; C07C49/743; C07C49/753; C07C49/755; C07C59/90; C07C69/007; C07C69/16; C07C69/96; C07C205/45; C07C323/22; C07C323/52; C07C323/58; C07D233/54; C07D317/72; C07D319/08; C07F7/18; C07H15/18
Domestic Patent References:
| JP62234040A | ||||
| JP5503077A |
Foreign References:
| WO1994018151A1 |
Other References:
Experientia (January 1996), 52(1), 75-80
Cancer Research (1987), 47(12), 3186-9
Journal of Organic Chemistry (1997), 62(9), 3015-3018
Tetrahedron Letters (1997), 38(10), 1697-1698
Journal of Natural Products (1996), 59(9), 896-899
Cancer Research (1987), 47(12), 3186-9
Journal of Organic Chemistry (1997), 62(9), 3015-3018
Tetrahedron Letters (1997), 38(10), 1697-1698
Journal of Natural Products (1996), 59(9), 896-899
Attorney, Agent or Firm:
Takashi Ishida
Fukumoto product
Toshio Toda
Masaya Nishiyama
Higuchi Souji
Fukumoto product
Toshio Toda
Masaya Nishiyama
Higuchi Souji