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Title:
IMIDATE DERIVATIVE OF PHRMACOLOGICALLY USEFUL, ANTICONVULSIVE SULFAMATE
Document Type and Number:
Japanese Patent JPH06271580
Kind Code:
A
Abstract:

PURPOSE: To provide new compds. useful for the treatment of epilepsy, etc., as a prodrug of anticonvulsant agents, which are converted to an active medicine exhibiting anticonvulsant activity in the body of mammals.

CONSTITUTION: The derivs. are the compds. of formula I (where R1 is 1-10C alkyl or 3-10C cycloalkyl; R2 is H, 1-10C alkyl or the like; R3 and R4 are each H, 1-6C alkyl or the like; X is CR5R6, S(R7)n(R8)p (R5 and R6 are each H, 1-4C perfluoroalkyl or the like; R7 and R8 are each O, NR9 (R9 is H, alkenesulfonyl or the like); n and p are each 0 or 1, however n and p are not 0 at the same time)) or these salts for example, 2,3;4,5-bis-0-(1-methylethylidene-β-D- fructopyranose N-(phenylmethoxymethylidene)sulfamate. The compd. are obtained for example, by reacting the sulfamate of formula II with the compd. of formula HC(OMe)3 (Me is CH3) at 50-150°C. Further, the compds. of formula II are obtained for example, by reacting the compds. of formula III with sulfamoyl chloride.


Inventors:
BURUUSU II MARIANOFU
Application Number:
JP1993000163316
Publication Date:
September 27, 1994
Filing Date:
June 08, 1993
Export Citation:
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Assignee:
MCNEILAB INC
International Classes:
A61K31/35; A61P25/08; A61P43/00; C07D493/14; C07D497/14; C07H9/04; C07H11/00; (IPC1-7): C07D493/14; A61K31/35; C07D497/14
Attorney, Agent or Firm:
Heiyoshi Odashima