Title:
JNKモジュレーターとしてのイミダゾ[1,2-a]ピリジン
Document Type and Number:
Japanese Patent JP5518905
Kind Code:
B2
Abstract:
Compounds of formula (I) modulate JNK wherein X1 and X2 are each simultaneously N or CH; X3 is CH-R2 Or N-SO2R, where R is lower alkyl; R1 is aryl or heteroaryl, substituted with 0-3 lower alkyl radicals; R2 is (II), where R3 is H, lower acyl, or an amino acid, or a pharmaceutically acceptable salt thereof.
Inventors:
Buttelmann, Bernd
Gouyal, Bindu
Palmer, Wiley Sorang
Gouyal, Bindu
Palmer, Wiley Sorang
Application Number:
JP2011551466A
Publication Date:
June 11, 2014
Filing Date:
February 19, 2010
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C07D471/04; A61K31/506; A61P11/00; A61P11/06; A61P17/00; A61P19/00; A61P19/02; A61P19/06; A61P25/04; A61P29/00; A61P31/04; A61P31/12; A61P31/22; A61P33/06; A61P35/00; A61P43/00
Foreign References:
| WO2006038001A1 | ||||
| WO2008168171A1 |
Other References:
ALAM,SYNTHESIS AND SAR OF AMINOPYRIMIDINES AS NOVEL C-JUN N-TERMINAL KINASE (JNK) INHIBITORS,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,英国,PERGAMON, ELSEVIER SCIENCE,2007年 6月15日,V17 N12,P3463-3467
BUCKLEY G M,IRAK-4 INHIBITORS. PART II: A STRUCTURE-BASED ASSESSMENT OF IMIDAZO[1,2-A]PYRIDINE BINDING,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,英国,PERGAMON, ELSEVIER SCIENCE,2008年 6月 1日,V18 N11,P3291-3295
BUCKLEY G M,IRAK-4 INHIBITORS. PART II: A STRUCTURE-BASED ASSESSMENT OF IMIDAZO[1,2-A]PYRIDINE BINDING,BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,英国,PERGAMON, ELSEVIER SCIENCE,2008年 6月 1日,V18 N11,P3291-3295
Attorney, Agent or Firm:
Hajime Tsukuni
Fusayuki Saito
Fusayuki Saito