イミダゾールカルボニル化合物

Japanese Patent JP5798221

B2

To develop an antibiotic having a novel mechanism of action, the present inventors have searched for a compound that has weak cytotoxicity, the physical property of high solubility in water, the effect of inhibiting both DNA gyrase GyrB and topoisomerase IV ParE subunits, and sufficient antibacterial activity. As a result, the present inventors have completed the present invention by finding that a compound of the present invention represented by the general formula (1), a pharmacologically acceptable salt thereof, and a prodrug thereof have desirable properties. The present invention provides a pharmaceutical composition (particularly, a preventive or therapeutic composition for infectious disease) comprising a compound represented by the formula (1), a pharmacologically acceptable salt thereof, or a prodrug thereof as an active ingredient.

Go Soneda
Yutaka Takeshita
Yoshiko Tokoshima
Yuko Yamamoto
Takashi Hosokawa
Toshiyuki Konosu
Nobuhisa Masuda
Takuya Uchida
Achinami Issei
Kuroyanagi Junichi
Tetsunori Fujisawa
Yokomizo Aki
Tetsuji Noguchi

JP2014149113A

October 21, 2015

July 22, 2014

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Daiichi Sankyo Co., Ltd.

C07D233/90; A61K31/4164; A61K31/4178; A61K31/427; A61K31/428; A61K31/437; A61K31/454; A61K31/4709; A61K31/496; A61K31/5025; A61K31/506; A61K31/519; A61K31/538; A61K31/5383; A61P31/00; A61P31/04; A61P43/00; C07D401/12; C07D401/14; C07D403/12; C07D405/12; C07D409/12; C07D409/14; C07D413/14; C07D417/14; C07D495/04; C07D495/16; C07D513/04; C07D519/00

WO2004041795A1
WO2006092608A1
WO2005003087A1
WO2005026149A1
WO2004018439A1

Kimiki Ishibashi
Noriko Kitano
Toshiyasu Takemoto
Hironobu Kodama
Reiko Kanehara

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