Title:
IMIDAZOLE COMPOUND, PRODUCTION AND USE THEREOF
Document Type and Number:
Japanese Patent JP3647051
Kind Code:
B2
Abstract:
PURPOSE: To provide the imidazole compounds having a valuable activity as calcium channel blocker and useful for treating stroke, anoxia, ischemia, migraine and epilepsy or the like.
CONSTITUTION: The compounds of the formula I, e.g. 1-[3-(3-aminophenyl)- phenyl]-5-trifluoromethyl-benzimidazole, are obtained by allowing the compounds of the formula II to react with formic acid or with its reactive derivative. In the formula I, X, Y are each C or N; R11 is H, OH or alkoxy; R12, R13 are each halogen, CF3, CN, OH, alkyl, NH2, NO2, sulfamoyl, substitutable phenylsulfonyl, substitutable phenyloxy, substitutable phenylamino, substitutable aryl or the like; R4-R7 are each H, halogen, NH2, NO2, CN, CF3COOH, COO- alkyl, alkyl, acyl, alkoxy, (CH2)n-OH, (CH2)m-O-aIkyl or (CH2)o-acyl ((n), (m), (o), are each 0 to 3).
Inventors:
Oscar Axelson
Dan Peters
Elsebeto Esthergirl Nielsen
Parle Christoph Helsen
Dan Peters
Elsebeto Esthergirl Nielsen
Parle Christoph Helsen
Application Number:
JP6568893A
Publication Date:
May 11, 2005
Filing Date:
March 24, 1993
Export Citation:
Assignee:
NEUROSEARCH A/S
International Classes:
A61K31/4184; A61K31/4188; A61K31/435; A61K31/437; A61K31/495; A61K31/496; A61P3/00; A61P3/14; A61P9/00; A61P9/10; A61P25/00; A61K31/415; A61P25/06; A61P25/08; A61P25/16; A61P25/18; A61P25/24; C07D235/06; C07D235/08; C07D401/10; C07D401/14; C07D409/04; C07D409/10; C07D471/04; C07D487/04; (IPC1-7): C07D235/08; A61K31/4188; A61K31/437; C07D471/04
Other References:
LUKASZ Kaczmarek et al,SYNTHESIS AND PHARMACOLOGICAL PROPERTIES OF SOME DERIVATIVES OF 3-PHENYLIMIDAZO[4,5-b]PYRIDINE,Pol.J.Pharmacol.Pharm.,1990年,Vol.42,No.1,p.79-84
Attorney, Agent or Firm:
Mitsufumi Esaki
Tsuneo Mihara
Okumura Yoshimichi
Blacksmith
Tsuneo Mihara
Okumura Yoshimichi
Blacksmith