Title:
局所領域的腫瘍治療後の免疫調節
Document Type and Number:
Japanese Patent JP7086077
Kind Code:
B2
Abstract:
The present invention concerns a thermosensitive polymeric hydrogel comprising at least one thermosensitive copolymer, one aqueous solution, and a mucoadhesive excipient, wherein said thermosensitive polymeric hydrogel further comprises at least one immunostimulatory adjuvant and/or at least one cytokine and/or at least one chemokine and/or atleast one heat shockprotein. Another object of the invention is a thermosensitive polymeric hydrogel according to the invention for use in the treatment of tumors or metastasis in a subject having a cancer, preferably a metastatic cancer.
Inventors:
Robert Malafos
Natalie Minje
Vincent Budi
Johann Segan
Katya Remdani
Claude Capron
Natalie Minje
Vincent Budi
Johann Segan
Katya Remdani
Claude Capron
Application Number:
JP2019532205A
Publication Date:
June 17, 2022
Filing Date:
August 31, 2017
Export Citation:
Assignee:
Anstituto Nacional de la Sante et de la Le Chalche Medical (Inselm)
Center National de la Cherche Sian Tiffic
UNIVERSITE PARIS DESCARTES
Assistance Public-Opito de Paris
Ecole Nacional Superior Wool de Simi de Paris
Universites de Versailles Saint-Quentin en Yvelines
Center National de la Cherche Sian Tiffic
UNIVERSITE PARIS DESCARTES
Assistance Public-Opito de Paris
Ecole Nacional Superior Wool de Simi de Paris
Universites de Versailles Saint-Quentin en Yvelines
International Classes:
A61K47/34; A61K9/06; A61K38/16; A61K38/19; A61K39/39; A61K45/00; A61K47/36; A61P1/00; A61P1/16; A61P1/18; A61P11/00; A61P13/12; A61P15/14; A61P19/08; A61P35/00; A61P35/04; A61P43/00
Domestic Patent References:
| JP2004538271A |
Other References:
Development of a successful antitumor therapeutic model combining in vivo dendritic cell vaccination with tumor irradiation and intratumoral GM-CSF delivery,Cancer Immunol Immunother,2011年,60(2),273-281
Sustained Delivery of Interleukin-2 from a Poloxamer 407 Gel Matrix Following Intraperitoneal Injection in Mice,Pharmaceutical Research,米国,1992年,9(3),425-434
Hematopoietic Progenitor Cell Mobilization in Mice by Sustained Delivery of Granulocyte Colony-Stimulating Factor,Journal of Interferon and Cytokine Research,2005年,25(8),490-500
Sustained Delivery of Interleukin-2 from a Poloxamer 407 Gel Matrix Following Intraperitoneal Injection in Mice,Pharmaceutical Research,米国,1992年,9(3),425-434
Hematopoietic Progenitor Cell Mobilization in Mice by Sustained Delivery of Granulocyte Colony-Stimulating Factor,Journal of Interferon and Cytokine Research,2005年,25(8),490-500
Attorney, Agent or Firm:
Murayama Yasuhiko
Shinya Mihiro
Tatsuhiko Abe
Shinya Mihiro
Tatsuhiko Abe