Title:
ドミナントネガティブＦａｓを発現する免疫応答性細胞およびその使用
Document Type and Number:
Japanese Patent JP2022502054
Kind Code:
A
Abstract:
本開示は、がんおよび病原体に対する免疫応答を増強するための方法および組成物を提供する。これは、抗原認識受容体（例えば、キメラ抗原受容体（ＣＡＲ）またはＴ細胞受容体（ＴＣＲ））およびドミナントネガティブＦａｓポリペプチドを含む細胞に関する。ある特定の実施形態では、細胞は、抗原指向性であり、増強された細胞持続性および増強された抗標的処置の有効性を示す。ある特定の実施形態では、ドミナントネガティブＦａｓポリペプチドは、細胞質死ドメイン中に少なくとも１つの改変を含む。
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Inventors:
Klebanov, Christopher A.
Yamamoto, Tori N.
Restifo, Nicholas P.
Yamamoto, Tori N.
Restifo, Nicholas P.
Application Number:
JP2021517344A
Publication Date:
January 11, 2022
Filing Date:
September 30, 2019
Export Citation:
Assignee:
Memorial Sloan Kettering Cancer Center
The United States of America, As Represented by The Secretary, Department of Health and Human Services
The United States of America, As Represented by The Secretary, Department of Health and Human Services
International Classes:
C12N5/10; A61K35/17; A61P35/00; A61P35/02; A61P37/04; C12N5/0783; C12N15/09; C12N15/12; C12N15/867
Domestic Patent References:
| JP2008543346A | 2008-12-04 |
Foreign References:
| WO2018170475A1 | 2018-09-20 | |||
| WO2017040945A1 | 2017-03-09 |
Other References:
MAEDA T ET AL.: "“Fas gene mutation in the progression of adult T cell leukemia.”", THE JOURNAL OF EXPERIMENTAL MEDICINE, vol. 189, no. 7, JPN6023029957, 5 April 1999 (1999-04-05), pages 1063 - 1071, ISSN: 0005111205
ITOH N ET AL.: "“A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen.”", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, no. 15, JPN6023029958, 25 May 1993 (1993-05-25), pages 10932 - 10937, XP002917499, ISSN: 0005111206
KHENG NEWICK ET AL.: "“Chimeric antigen receptor T-cell therapy for solid tumors”", #16006, vol. 3, JPN6023029959, 2016, pages 1 - 7, ISSN: 0005111207
AYA YOKOTA ET AL.: "“Prominent dominantnegative effect of a mutant Fas molecule lacking death domain on cell-mediated i", MOLECULAR IMMUNOLOGY, vol. 42, no. 1, JPN6023029960, January 2005 (2005-01-01), pages 71 - 78, ISSN: 0005111208
AMY P. HSU ET AL.: "“Autoimmune lymphoproliferative syndrome due to FAS mutations outside thesignal-transducing death d", GENETICS IN MEDICINE, vol. 14, no. 1, JPN6023029956, January 2012 (2012-01-01), pages 81 - 89, ISSN: 0005111209
ITOH N ET AL.: "“A novel protein domain required for apoptosis. Mutational analysis of human Fas antigen.”", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 268, no. 15, JPN6023029958, 25 May 1993 (1993-05-25), pages 10932 - 10937, XP002917499, ISSN: 0005111206
KHENG NEWICK ET AL.: "“Chimeric antigen receptor T-cell therapy for solid tumors”", #16006, vol. 3, JPN6023029959, 2016, pages 1 - 7, ISSN: 0005111207
AYA YOKOTA ET AL.: "“Prominent dominantnegative effect of a mutant Fas molecule lacking death domain on cell-mediated i", MOLECULAR IMMUNOLOGY, vol. 42, no. 1, JPN6023029960, January 2005 (2005-01-01), pages 71 - 78, ISSN: 0005111208
AMY P. HSU ET AL.: "“Autoimmune lymphoproliferative syndrome due to FAS mutations outside thesignal-transducing death d", GENETICS IN MEDICINE, vol. 14, no. 1, JPN6023029956, January 2012 (2012-01-01), pages 81 - 89, ISSN: 0005111209
Attorney, Agent or Firm:
Hidesaku Yamamoto
Natsuki Morishita
Natsuki Morishita