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Title:
クラミジア感染に対する免疫
Document Type and Number:
Japanese Patent JP2007511227
Kind Code:
A
Abstract:
The present invention provides nucleic acids, proteins and vectors for a method of nucleic acid, including DNA, immunization of a host, including humans, against disease caused by infection by a strain of Chlamydia, specifically C. trachomatis. The method employs a vector containing a nucleotide sequence encoding a Mgp002 polypeptide of a strain of Chlamydia operably linked to a promoter to effect expression of the gene product in the host. Truncated forms of the full-length Mgp002 gene are useful immunogens for protecting against disease caused by infection with Chlamydia. The invention further provides recombinant Mgp002 protein useful for protecting against disease caused by infection with Chlamydia.

Inventors:
Branham, Robert Sea
Lord Nikine, Ausra
Galichan, scott
Andrew, Mardin
Application Number:
JP2006540117A
Publication Date:
May 10, 2007
Filing Date:
November 19, 2004
Export Citation:
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Assignee:
SANOFI PASTEUR LIMITED
International Classes:
C12N15/09; A61K39/118; A61K39/39; A61P31/10; C07K14/295; C07K16/12; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; A61K39/00
Domestic Patent References:
JP2002517179A2002-06-18
JP2003510050A2003-03-18
Foreign References:
WO2003049762A22003-06-19
WO2002002606A22002-01-10
Other References:
JPN6010044758, GenBank Acession No.A81682 (11−MAY−2000)(http://www.ncbi.nlm.nih.gov/sviewer/viewer.fcgi?val=112821
JPN6010044759, GenBank Acession No.G71525 (04−FEB−2000)(http://www.ncbi.nlm.nih.gov/sviewer/viewer.fcgi?val=746899
JPN6010044760, Science, 282 (1998) p.754−759
JPN6010044761, Nucleic Acids Res., 28[6] (2000) p.1397−1406
Attorney, Agent or Firm:
Yanagita Seiji
Go Sakuma