Title:
免疫誘導剤及びそれを含む医薬組成物
Document Type and Number:
Japanese Patent JP7184366
Kind Code:
B2
Abstract:
Disclosed is an immunity-inducing agent having excellent ease of production and high immunostimulatory activity, the immunity-inducing agent comprising, as an active component, a polynucleotide/peptide conjugate in which an antigenic peptide is covalently bound to a single-stranded polynucleotide or polynucleotide derivative. Also disclosed is a pharmaceutical composition comprising said immunity-inducing agent.
Inventors:
Shinichi Mochizuki
Kazuo Sakurai
Hiromi Morishita
Kazuo Sakurai
Hiromi Morishita
Application Number:
JP2019509625A
Publication Date:
December 06, 2022
Filing Date:
March 20, 2018
Export Citation:
Assignee:
Kitakyushu City University
International Classes:
A61K39/00; A61K39/39; A61K47/56; A61P37/04; C07K14/47; C07K14/82
Foreign References:
| WO2015118789A1 | ||||
| US20150191730 | ||||
| WO2017217531A1 |
Other References:
MOCHIZUKI S.et al.,Immunization with antigenic peptides complexed with β-glucan induces potent cytotoxic T-lymphocyte activity in combination with CpG-ODNs,Journal of Controlled Release,2015年,220,p.495-502
KHAN S.et al.,Distinct uptake mechanisms but similar intracellular processing of two different Toll-like receptor ligand-peptide conjugates in dendritic cells,J Biol Chem.,2007年07月20日,282(29),p.21145-59
KRAMER K.et al.,Intracellular cleavable CpG oligodeoxynucleotide-antigen conjugate enhances anti-tumor immunity,Mol Ther.,2017年01月04日,25(1),p.62-70
TIGHE H.et al.,Conjugation of immunostimulatory DNA to the short ragweed allergen Amb a 1 enhances its immunogenicicity and reduces its allergenicity,J Allergy Clin Immunol.,2000年07月,106(1 Pt 1),p.124-34
KHAN S.et al.,Distinct uptake mechanisms but similar intracellular processing of two different Toll-like receptor ligand-peptide conjugates in dendritic cells,J Biol Chem.,2007年07月20日,282(29),p.21145-59
KRAMER K.et al.,Intracellular cleavable CpG oligodeoxynucleotide-antigen conjugate enhances anti-tumor immunity,Mol Ther.,2017年01月04日,25(1),p.62-70
TIGHE H.et al.,Conjugation of immunostimulatory DNA to the short ragweed allergen Amb a 1 enhances its immunogenicicity and reduces its allergenicity,J Allergy Clin Immunol.,2000年07月,106(1 Pt 1),p.124-34
Attorney, Agent or Firm:
Osamu Yamamoto
Toru Miyamae
Motoharu Nakanishi
Nakamura
Ichinomiya Ichinomiya
Toru Miyamae
Motoharu Nakanishi
Nakamura
Ichinomiya Ichinomiya