IMMUNOASSAY FOR LSD AND 2-OXO-3-HYDROXY-LSD

Title:

IMMUNOASSAY FOR LSD AND 2-OXO-3-HYDROXY-LSD

Document Type and Number:

Japanese Patent JP2002003500

Kind Code:

A

Abstract:

To obtain a new lysergic acid diethylamide(LSD) and an iso-LSD, a new hapten and a new immunogen of an oxidized LSD and an antibody derived from the immunogen and to provide a method for immunoassay utilizing the antibody.

This hapten derivative is useful for preparing the antigen, the antibody and a reagent used for the immunoassay for detecting the LSD and 2-oxo-3-hydroxy-LSD. The 2-oxy-LSD nucleus is derivatized from an indole nitrogen to form an aminoalkyl derivative. The resultant hapten is subsequently further modified at a functionalized position for connection thereof to a suitable immunogenic group or a labeling group to afford the reagent for the immunoassay having substantially equal specificity for both the LD and the 2-oxo-3-hydroxy-LSD.

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Inventors:

GHOSHAL MITALI
VITONE STEPHEN
SIGLER GERALD F
MCNALLY ALAN J

Application Number:

JP2001108813A

Publication Date:

January 09, 2002

Filing Date:

April 06, 2001

Export Citation:

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Assignee:

ROCHE DIAGNOSTICS CORP

International Classes:

C07D457/06; C07K14/435; C07K14/765; C07K14/795; C07K16/44; C08B30/18; C12P21/08; G01N33/531; G01N33/94; G01N33/53; C12R1/91; (IPC1-7): C07K14/765; C07D457/06; C07K14/435; C07K14/795; C07K16/44; C08B30/18; G01N33/53; G01N33/531

Attorney, Agent or Firm:

Yusuke Hiraki (1 person outside)

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