ヒトメソセリンを特異的に認識する細胞表面分子、ＩＬ－７、及びＣＣＬ１９を発現する免疫担当細胞

Japanese Patent JP7233720

B2

An object of the present invention is to provide an immunocompetent cell targeting mesothelin. An immunocompetent cell that expresses a cell surface molecule specifically recognizing human mesothelin, interleukin 7 (IL-7), and chemokine (C-C motif) ligand 19 (CCL19) is produced. It is preferred that: the cell surface molecule specifically recognizing human mesothelin should be chimeric antigen receptor (CAR) having single chain antibody, a transmembrane region, and a signaling region that induces the activation of the immunocompetent cell; and the heavy chain variable region and the light chain variable region should be connected via a peptide linker consisting of a 2-to 30-amino acid sequence.

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Koji Tamada
Yukimi Sakoda
Keishi Adachi

JP2019560545A

March 07, 2023

December 19, 2018

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Noil Immun Biotech Co., Ltd.

C12N15/63; A61K35/17; A61P35/00; C07K14/52; C07K14/54; C07K14/705; C07K16/28; C07K19/00; C12N5/0783; C12N5/10; C12N15/12; C12N15/13; C12N15/19; C12N15/24; C12N15/62

JP2011504372A
JP2013517317A

WO2016056228A1
WO2013063419A2
WO2008143684A1
WO2017177149A2
WO2010028795A1
WO2017159736A1

Hiroki Masaki
Teppei Hirota
Seiji Ozawa
Yusaku Tokai
Matsunashi Yasunori
Horiuchi Makoto
Masako Yamauchi
Shuichi Sonomoto
Akihiro Yamamura
Hiroyuki Tomita
Maki Shinoda

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