Title:
IMMUNOGENIC COMPOSITIONS AGAINST HELICOBACTER INFECTION, POLYPEPTIDES FOR USE IN THE COMPOSITIONS AND NUCLEIC ACID SEQUENCES ENCODING SAID POLYPEPTIDES
Document Type and Number:
Japanese Patent JP2004337170
Kind Code:
A
Abstract:
To provide an immunogenic composition, capable of inducing protective antibodies against Helicobacter infection, and to provide a method for preparation of the immunogenic composition by means of recombination.
The immunogenic composition comprises: (i) at least one sub-unit of a urease structural polypeptide from Helicobacter pylori, or a fragment thereof, said fragment being recognised by antibodies reacting with Helicobacter felis urease, and/or at least one sub-unit of a urease structural polypeptide from Helicobacter felis, or a fragment thereof, said fragment being recognised by antibodies reacting with Helicobacter pylori urease, (ii) and/or Heat Shock Protein (HSP), chaperonin, from Helicobacter pylori, or a fragment of said protein.
Inventors:
LABIGNE AGNES
SUERBAUM SEBASTIEN
FERRERO RICHARD
THIBERGE JEAN-MICHEL
Application Number:
JP2004164306A
Publication Date:
December 02, 2004
Filing Date:
June 02, 2004
Assignee:
PASTEUR INSTITUT
INST NAT SANTE RECH MED
International Classes:
C12N15/09; A61K38/00; A61K39/00; A61K39/02; A61K39/106; A61K39/39; A61K39/395; A61P1/04; A61P3/02; A61P31/04; A61P35/00; A61P37/02; C07H21/04; C07K14/195; C07K14/205; C07K16/12; C07K16/40; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/80; C12N15/31; C12P21/02; C12P21/08; C12Q1/68; G01N33/569; G01N33/574; C12R1/19; (IPC1-7): C12N15/09; A61K38/00; A61K39/00; A61K39/39; A61K39/395; A61P1/04; A61P35/00; A61P37/02; C07K14/205; C07K16/12; C07K16/40; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/80; C12Q1/68
Attorney, Agent or Firm:
Takehiko Suzue
Sadao Muramatsu
Ryo Hashimoto
