Title:
ガレクチン-3の免疫アッセイ
Document Type and Number:
Japanese Patent JP2012507724
Kind Code:
A
Abstract:
The present invention relates to methods and compositions for specifically and quantitatively detecting galectin-3 in a sample. Embodiments of the invention include a detection assay in which a capture binding moiety and a labeled binding moiety specifically recognize non-overlapping epitopes on the N-terminus of galectin-3. Further embodiments are directed to a method for establishing ranges of galectin-3 concentrations indicative of the presence and severity of heart failure in a subject and a method for predicting the clinical outcome of a subject based upon galectin-3 concentration.
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Inventors:
Muntendam, Peter
Application Number:
JP2011534781A
Publication Date:
March 29, 2012
Filing Date:
October 29, 2009
Export Citation:
Assignee:
BG Medicine, Incorporated
International Classes:
G01N33/53; G01N33/532; G01N33/535; C07K14/47
Domestic Patent References:
| JP2004198313A | 2004-07-15 | |||
| JP2007508527A | 2007-04-05 |
Other References:
JPN6007000954; Ｃｖｅｊｉｃ， Ｄ．， ｅｔ ａｌ．: 'Ｉｍｍｕｎｏｈｉｓｔｏｃｈｅｍｉｃａｌ ｌｏｃａｌｉｚａｔｉｏｎ ｏｆ ｇａｌｅｃｔｉｎ-３ ｉｎ ｍａｌｉｇｎａｎｔ ａｎｄ ｂｅｎｉｇｎ ｈｕｍａｎ ｔｈｙｒｏｉｄ ｔｉｓｓｕｅ' Ａｎｔｉｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１８, 1998, ｐ．２６３７-２６４１
JPN6014009256; ｖａｎ Ｋｉｍｍｅｎａｄｅ ＲＲ， Ｊａｎｕｚｚｉ ＪＬ Ｊｒ， Ｅｌｌｉｎｏｒ ＰＴ， Ｓｈａｒｍａ ＵＣ， Ｂａｋｋｅｒ ＪＡ， Ｌｏｗ ＡＦ， Ｍａｒｔｉｎｅｚ Ａ， Ｃｒｉｊｎｓ ＨＪ， Ｍａ: 'Ｕｔｉｌｉｔｙ ｏｆ ａｍｉｎｏ-ｔｅｒｍｉｎａｌ ｐｒｏ-ｂｒａｉｎ ｎａｔｒｉｕｒｅｔｉｃ ｐｅｐｔｉｄｅ， ｇａｌｅｃｔｉｎ-３， ａｎｄ ａｐｅｌｉｎ ｆｏｒ ｔｈｅ ｅｖａｌｕａｔｉｏｎ ｏ' Ｊ Ａｍ Ｃｏｌｌ Ｃａｒｄｉｏｌ． Ｖｏｌ．４８，Ｎｏ．６, 200609, Ｐａｇｅ．１２１７-１２２４
JPN6014009255; Ｔａｋｅｎａｋａ Ｙ， Ｆｕｋｕｍｏｒｉ Ｔ， Ｒａｚ Ａ．: 'Ｇａｌｅｃｔｉｎ-３ ａｎｄ ｍｅｔａｓｔａｓｉｓ．' Ｇｌｙｃｏｃｏｎｊ Ｊ． Ｖｏｌ．１９, 2004, Ｐａｇｅ．５４３-５４９
JPN6014054946; Ｍａｔａｒｒｅｓｅ Ｐ， Ｆｕｓｃｏ Ｏ， Ｔｉｎａｒｉ Ｎ， Ｎａｔｏｌｉ Ｃ， Ｌｉｕ ＦＴ， Ｓｅｍｅｒａｒｏ ＭＬ， Ｍａｌｏｒｎｉ Ｗ， Ｉａｃｏｂｅｌｌｉ Ｓ．: 'Ｇａｌｅｃｔｉｎ-３ ｏｖｅｒｅｘｐｒｅｓｓｉｏｎ ｐｒｏｔｅｃｔｓ ｆｒｏｍ ａｐｏｐｔｏｓｉｓ ｂｙ ｉｍｐｒｏｖｉｎｇ ｃｅｌｌ ａｄｈｅｓｉｏｎ ｐｒｏｐｅｒｔｉｅｓ．' Ｉｎｔ Ｊ Ｃａｎｃｅｒ． Ｖｏｌ．８５，Ｎｏ．４, 20000215, Ｐａｇｅ．５４５-５５４
JPN6014009256; ｖａｎ Ｋｉｍｍｅｎａｄｅ ＲＲ， Ｊａｎｕｚｚｉ ＪＬ Ｊｒ， Ｅｌｌｉｎｏｒ ＰＴ， Ｓｈａｒｍａ ＵＣ， Ｂａｋｋｅｒ ＪＡ， Ｌｏｗ ＡＦ， Ｍａｒｔｉｎｅｚ Ａ， Ｃｒｉｊｎｓ ＨＪ， Ｍａ: 'Ｕｔｉｌｉｔｙ ｏｆ ａｍｉｎｏ-ｔｅｒｍｉｎａｌ ｐｒｏ-ｂｒａｉｎ ｎａｔｒｉｕｒｅｔｉｃ ｐｅｐｔｉｄｅ， ｇａｌｅｃｔｉｎ-３， ａｎｄ ａｐｅｌｉｎ ｆｏｒ ｔｈｅ ｅｖａｌｕａｔｉｏｎ ｏ' Ｊ Ａｍ Ｃｏｌｌ Ｃａｒｄｉｏｌ． Ｖｏｌ．４８，Ｎｏ．６, 200609, Ｐａｇｅ．１２１７-１２２４
JPN6014009255; Ｔａｋｅｎａｋａ Ｙ， Ｆｕｋｕｍｏｒｉ Ｔ， Ｒａｚ Ａ．: 'Ｇａｌｅｃｔｉｎ-３ ａｎｄ ｍｅｔａｓｔａｓｉｓ．' Ｇｌｙｃｏｃｏｎｊ Ｊ． Ｖｏｌ．１９, 2004, Ｐａｇｅ．５４３-５４９
JPN6014054946; Ｍａｔａｒｒｅｓｅ Ｐ， Ｆｕｓｃｏ Ｏ， Ｔｉｎａｒｉ Ｎ， Ｎａｔｏｌｉ Ｃ， Ｌｉｕ ＦＴ， Ｓｅｍｅｒａｒｏ ＭＬ， Ｍａｌｏｒｎｉ Ｗ， Ｉａｃｏｂｅｌｌｉ Ｓ．: 'Ｇａｌｅｃｔｉｎ-３ ｏｖｅｒｅｘｐｒｅｓｓｉｏｎ ｐｒｏｔｅｃｔｓ ｆｒｏｍ ａｐｏｐｔｏｓｉｓ ｂｙ ｉｍｐｒｏｖｉｎｇ ｃｅｌｌ ａｄｈｅｓｉｏｎ ｐｒｏｐｅｒｔｉｅｓ．' Ｉｎｔ Ｊ Ｃａｎｃｅｒ． Ｖｏｌ．８５，Ｎｏ．４, 20000215, Ｐａｇｅ．５４５-５５４
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita