Title:
IMMUNOLOGICALLY ACTIVE PEPTIDYLDISACCHARIDES AND THEIR MANUFACTURE
Document Type and Number:
Japanese Patent JPS55145696
Kind Code:
A
Abstract:
2-Amino-2-deoxy- beta -D-glucopyranosyl-(1-4)-2-amino-2-deoxy-D-glucoses of the general structural formula: wherein R1 is hydrogen, alkyl (1-7C), substituted alkyl (1-7C), phenyl, substituted phenyl, benzyl, or substituted benzyl; R2 is alkyl, substituted alky, phenyl, or substituted phenyl and each R2 may be the same group or a different group; R3 is H or wherein R8 is H or lower alkyl (1-10C), and provided at least one of R3 is not H, R9 is H, or R9-R10 together is -CH2-CH2-CH2-; R10 is H, alkyl (L-7C), hydroxymethyl, mercaptomethyl, benzyl, or substituted benzyl; R11 and R12 each is carboxyl, esterified carboxyl (1-7C), amidated carboxyl, or mono- or di-alkyl- (1-3C) amidated carboxyl; R4 and R5 are the same or different and are H, aliphatic or aromatic acyl (2-21C) or substituted acyl (2-21C); when R8 is lower alkyl, the stereochemistry at asymmetric center I can be either D or L; when R10 is not H, the stereochemistry at asymmetric center II is L; the stereochemistry at asymmetric center III is D. These compounds possess immunostimulatory properties.
Inventors:
FUIRITSUPU ERU DEYURETSUTO
TSUNNYUN SHIEN
TSUNNYUN SHIEN
Application Number:
JP5554480A
Publication Date:
November 13, 1980
Filing Date:
April 28, 1980
Export Citation:
Assignee:
MERCK & CO INC
International Classes:
A61K31/70; A61K39/39; A61P31/04; C07H13/00; C07H15/00; C07K1/113; C07K9/00; (IPC1-7): A61K31/70; A61K39/39; C07H15/04; C07H15/18; C07H15/20