Title:
IMMUNOMODULATION USING PLACENTAL STEM CELL
Document Type and Number:
Japanese Patent JP2015131795
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide compositions for immunomodulation effective for graft-versus-host disease, autoimmune disease, diabetes, lupus erythematosus, rheumatoid arthritis or multiple sclerosis.SOLUTION: This invention relates to methods to treat the diseases by screening a plurality of placental stem cells that can inhibit T cell proliferation in a mixed lymphocyte reaction (MLR) assay in vitro and inhibiting immune response using pharmaceutical compositions comprising selected placental stem cells.
Inventors:
PALUDAN CASPER
EDINGER JAMES
HARBACHEUSKI RYHOR
MURRAY ROSEANN
HARIRI ROBERT J
EDINGER JAMES
HARBACHEUSKI RYHOR
MURRAY ROSEANN
HARIRI ROBERT J
Application Number:
JP2014198303A
Publication Date:
July 23, 2015
Filing Date:
September 29, 2014
Export Citation:
Assignee:
ANTHROGENESIS CORP
International Classes:
A61K35/50; A61K35/12; A61K39/395; A61P3/10; A61P19/02; A61P25/00; A61P29/00; A61P37/02; A61P37/06; C12N5/073
Domestic Patent References:
| JP2005517402A | 2005-06-16 | |||
| JP2004359641A | 2004-12-24 |
Other References:
JPN5008016201; Ｌｉ ＣＤ， ｅｔ ａｌ．: 'Ｍｅｓｅｎｃｈｙｍａｌ ｓｔｅｍ ｃｅｌｌｓ ｄｅｒｉｖｅｄ ｆｒｏｍ ｈｕｍａｎ ｐｌａｃｅｎｔａ ｓｕｐｐｒｅｓｓ ａｌｌｏｇｅｎｅｉｃ ｕｍｂｉｌｉｃａｌ ｃｏｒｄ ｂｌｏｏｄ ｌｙｍｐｈｏｃｙ' Ｃｅｌｌ Ｒｅｓｅａｒｃｈ Ｖｏｌ． １５， Ｎｏ． ７, 200507, ｐｐ． ５３９-５４７
JPN5008016199; Ｅｘｐｅｒｉｍｅｎｔａｌ Ｈｅｍａｔｏｌｏｇｙ Ｖｏｌ． ３２， Ｎｏ． ７, 2004, ｐｐ． ６５７-６６４
JPN5008016199; Ｅｘｐｅｒｉｍｅｎｔａｌ Ｈｅｍａｔｏｌｏｇｙ Ｖｏｌ． ３２， Ｎｏ． ７, 2004, ｐｐ． ６５７-６６４
Attorney, Agent or Firm:
Toru Ishikawa