Title:
トール様受容体に基づく免疫反応を調整する免疫調節ヌクレオチド（ＩＲＯ）化合物
Document Type and Number:
Japanese Patent JP6406793
Kind Code:
B2
Abstract:
The invention provides novel immune regulatory oligonucleotides (IRO) as antagonist of TLRs and methods of use thereof. These IROs have unique sequences that inhibit or suppress TLR-mediated signaling in response to a TLR ligand or TLR agonist. The methods may have use in the prevention and treatment of cancer, an autoimmune disorder, airway inflammation, inflammatory disorders, infectious disease, skin disorders, allergy, asthma or a disease caused by a pathogen.
Inventors:
Candimalla, Ecumber, Earl.
Dakin, one
Li, Yuki
You, Don
Fugan
Lakshmi, Bagat
Sadir, Agrawar
Dakin, one
Li, Yuki
You, Don
Fugan
Lakshmi, Bagat
Sadir, Agrawar
Application Number:
JP2008535681A
Publication Date:
October 17, 2018
Filing Date:
October 12, 2006
Export Citation:
Assignee:
Idera Pharmaceuticals, Inc.
International Classes:
A61K31/7125; A61K31/7088; A61K35/76; A61K39/00; A61K45/00; A61K48/00; A61P11/00; A61P11/06; A61P17/00; A61P29/00; A61P31/00; A61P35/00; A61P37/04; A61P37/06; A61P37/08
Foreign References:
| WO2004094671A2 | ||||
| WO2005007672A2 | ||||
| WO2003103708A1 | ||||
| US20040097719 |
Attorney, Agent or Firm:
Kiyoji Kuzuwa