Title:
Immunomodulatory properties of pluripotent adult progenitor cells and their use
Document Type and Number:
Japanese Patent JP6342880
Kind Code:
B2
Abstract:
Isolated cells are described that are not embryonic stem cells, not embryonic germ cells, and not germ cells. The cells can differentiate into at least one cell type of each of at least two of the endodermal, ectodermal, and mesodermal lineages. The cells do not provoke a harmful immune response. The cells can modulate immune responses. As an example, the cells can suppress an immune response in a host engendered by allogeneic cells, tissues, and organs. Methods are described for using the cells, by themselves or adjunctively, to treat subjects. For instance, the cells can be used adjunctively for immunosuppression in transplant therapy. Methods for obtaining the cells and compositions for using them also are described.
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Inventors:
Robert Danes
Van Hof, water
Magicals, Richard
Kovaxovics, Magdalena
Streator, Philip
Van Hof, water
Magicals, Richard
Kovaxovics, Magdalena
Streator, Philip
Application Number:
JP2015246808A
Publication Date:
June 13, 2018
Filing Date:
December 18, 2015
Export Citation:
Assignee:
Athersys, Incorporated
Oregon Health and Science University
Oregon Health and Science University
International Classes:
A61K35/12; A61K35/14; A61K35/26; A61K35/28; A61K35/30; A61K35/407; A61K35/50; A61K35/51; A61K39/00; A61P7/00; A61P7/06; A61P19/00; A61P35/00; A61P35/02; A61P37/02; A61P37/06
Attorney, Agent or Firm:
Yusuke Hiraki
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Yumi Naito
Satoshi Fujita
Eiichi Arai
Natsuo Tanaka
Yumi Naito