Title:
免疫刺激オリゴヌクレオチド、その組成物およびその使用方法
Document Type and Number:
Japanese Patent JP4101888
Kind Code:
B2
Abstract:
The invention relates to oligonucleotides which comprise a hexameric nucleotide sequence of the formula 5'-Purine-Purine-[Y]-[Z]-Pyrimidine-Pyrimidine-3' or 5' Purine-Purine-[Y]-[Z]-poly(Pyrimidine)-3'; wherein Y is any naturally occurring or synthetic nucleotide except cytosine and Z is any naturally occurring or synthetic nucleotide and wherein when Y is not guanosine or inosine, Z is guanosine or inosine. The oligonucleotides are useful in method of treatments including for reducing inflammation in a host; treating an autoimmune disorder; or inducing a Th2 immune response to an extracellular antigen. Exemplary hexameric nucleotide sequences include AAGGTT, AAGGTC, AAGGCC, AGGGTT, AGGGTC, AGGGCT, GGGGTT, GGGGTC, GGGGCT, GAGGTT, GAGGTC, GAGGCC, AAGCTT, AAGCTC, AAGCCC, AAGCCT, AGGCTC, AGGCCC, AGGCCT, GGGCTT, GGGCTC, GGGCCC, GAGCTT, GAGCTC, GAGCCC, and GAGCCT.
Inventors:
Schwartz, David
Roman mark
Dina, Dino
Razz, Isle
Roman mark
Dina, Dino
Razz, Isle
Application Number:
JP50288499A
Publication Date:
June 18, 2008
Filing Date:
June 05, 1998
Export Citation:
Assignee:
Dynabux Technologies Corporation
International Classes:
C12N15/09; A61K31/7052; A61K31/7088; A61K31/7115; A61K39/39; A61K48/00; A61P37/02; A61P37/06; A61P43/00; C07H21/00; C07K14/00; C07K14/47; C12N15/117; C12Q1/68; A61K38/00; C12Q1/6883
Foreign References:
| WO1998016247A1 | ||||
| WO1996002555A1 |
Other References:
Science, vol.273, pp.352-354 (1996)
Nature, vol.374, pp.546-549 (1995)
Nature, vol.374, pp.546-549 (1995)
Attorney, Agent or Firm:
Takashi Ishida
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji