Title:
修飾された免疫刺激性ジヌクレオチドを含む、オリゴヌクレオチドに基づく化合物の免疫刺激特性
Document Type and Number:
Japanese Patent JP2009514525
Kind Code:
A
Abstract:
The invention relates to the therapeutic use of oligonucleotides as immunostimulatory agents in immunotherapy applications. More particularly, the invention provides an immunostimulatory oligonucleotides for use in methods for generating an immune response or for treating a patient in need of immunostimulation. The immunostimulatory oligonucleotides of the invention preferably comprise novel purines. The immunostimulatory oligonucleotides according to the invention further comprise at least two oligonucleotides linked at their 3' ends, internucleoside linkages or functionalized nucleobase or sugar to a non-nucleotidic linker, at least one of the oligonucleotides being an immunostimulatory oligonucleotide and having an accessible 5' end.
Inventors:
Agrawal, Sadir
You Don
Candi Mara, Ekanbar, Earl.
You Don
Candi Mara, Ekanbar, Earl.
Application Number:
JP2008538854A
Publication Date:
April 09, 2009
Filing Date:
November 07, 2005
Export Citation:
Assignee:
Idera Pharmaceuticals, Inc.
International Classes:
C12N15/09; A61K31/7088; A61K48/00; A61P11/04; A61P11/06; A61P17/00; A61P29/00; A61P31/00; A61P35/00; A61P37/02; A61P37/08
Domestic Patent References:
| JP2005518402A | 2005-06-23 |
Foreign References:
| US20030225016A1 | 2003-12-04 | |||
| WO2004064782A2 | 2004-08-05 |
Other References:
JPN6011023773; 村松正實 他編 「分子細胞生物学辞典」， 東京化学同人， ２００２年， １５８ページ
JPN6011023775; 八杉龍一 他編 「岩波生物学辞典 第４版」， 岩波書店， １９９７年， １７０ページ
JPN6011023764; Ｎｕｃｌｅｉｃ Ａｃｉｄｓ Ｒｅｓ．， ２００２年， 第３０巻， ４４６０-４４６９ページ
JPN6011023766; Ｐｒｏｃ Ｎａｔｌ Ａｃａｄ Ｓｃｉ ＵＳＡ．， ２００３年， 第１００巻， １４３０３-１４３０８ページ
JPN6011023768; Ｐｒｏｃ Ｎａｔｌ Ａｃａｄ Ｓｃｉ ＵＳＡ．， ２００５年５月， 第１０２巻， ６９２５-６９３０ページ
JPN6011023770; Ｖａｃｃｉｎｅ， ２００５年４月， 第２３巻， ２６１４-２６２２ページ
JPN6011023772; Ｃｅｌｌ Ｉｍｍｕｎｏｌ．， ２０１０年， 第２６３巻， １０５-１１３ページ
JPN6011023775; 八杉龍一 他編 「岩波生物学辞典 第４版」， 岩波書店， １９９７年， １７０ページ
JPN6011023764; Ｎｕｃｌｅｉｃ Ａｃｉｄｓ Ｒｅｓ．， ２００２年， 第３０巻， ４４６０-４４６９ページ
JPN6011023766; Ｐｒｏｃ Ｎａｔｌ Ａｃａｄ Ｓｃｉ ＵＳＡ．， ２００３年， 第１００巻， １４３０３-１４３０８ページ
JPN6011023768; Ｐｒｏｃ Ｎａｔｌ Ａｃａｄ Ｓｃｉ ＵＳＡ．， ２００５年５月， 第１０２巻， ６９２５-６９３０ページ
JPN6011023770; Ｖａｃｃｉｎｅ， ２００５年４月， 第２３巻， ２６１４-２６２２ページ
JPN6011023772; Ｃｅｌｌ Ｉｍｍｕｎｏｌ．， ２０１０年， 第２６３巻， １０５-１１３ページ
Attorney, Agent or Firm:
Kiyoji Kuzuwa