Title:
インドールアミン2,3-ジオキシゲナーゼに基づく免疫療法
Document Type and Number:
Japanese Patent JP2011520783
Kind Code:
A
Abstract:
The present invention relates to the field of prophylaxis and therapy of cancer. In particular there is provided a protein Indoleamine 2,3-dioxygenase (IDO) or peptide fragments here of that are capable of eliciting anti-cancer immune responses. Specifically, the invention relates to the use of IDO or peptides derived here from or IDO specific T-cells for treatment of cancer. The invention thus relates to an anti-cancer vaccine which optionally may be used in combination with other immunotherapies and to IDO specific T-cells adoptively transferred or induced in vivo by vaccination as a treatment of cancer. It is an aspect of the invention that the medicaments herein provided may be used in combination with cancer chemotherapy treatment. A further aspect relates to the prophylaxis and therapy of infections by the same means as described above.The use of IDO and immunogenic peptide fragments hereof in cancer and infection treatment, diagnosis and prognosis is also provided.
Inventors:
Andersen, Mazhard
Straten, Pale sole
Straten, Pale sole
Application Number:
JP2011504314A
Publication Date:
July 21, 2011
Filing Date:
April 17, 2009
Export Citation:
Assignee:
Erref Hospital
International Classes:
A61K39/00; A61P35/00; C07K7/06; C07K14/725; C07K16/40; C12N9/02; C12N15/09; C12Q1/02; G01N33/574
Other References:
JPN6013049255; Ｃｌｉｎｉｃａｌ Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１２，Ｎｏ．４, 2006, ｐ１１４４-１１５１
JPN6013049258; Ｃｌｉｎｉｃａｌ Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１１，Ｎｏ．１６, 2005, ｐ６０３０-６０３９
JPN6013049261; Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．１６４，Ｎｏ．７, 2000, ｐ３５９６-３５９９
JPN6013049263; 実験医学 Ｖｏｌ．２０，Ｎｏ．１３, 2002, ｐ１９４７-１９５１
JPN6013049266; Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｖｏｌ．５６，Ｎｏ．１１, 1996, ｐ２４７９-２４８３
JPN6013049268; Ｂｉｏｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｐｈｙｓｉｃａｌ Ｒｅｓｅａｒｃｈ Ｃｏｍｍｕｎｉｃａｔｉｏｎ Ｖｏｌ．２０４，Ｎｏ．２, 1994, ｐ７１０-７１５
JPN6013049258; Ｃｌｉｎｉｃａｌ Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｖｏｌ．１１，Ｎｏ．１６, 2005, ｐ６０３０-６０３９
JPN6013049261; Ｊｏｕｒｎａｌ ｏｆ Ｉｍｍｕｎｏｌｏｇｙ Ｖｏｌ．１６４，Ｎｏ．７, 2000, ｐ３５９６-３５９９
JPN6013049263; 実験医学 Ｖｏｌ．２０，Ｎｏ．１３, 2002, ｐ１９４７-１９５１
JPN6013049266; Ｃａｎｃｅｒ Ｒｅｓｅａｒｃｈ Ｖｏｌ．５６，Ｎｏ．１１, 1996, ｐ２４７９-２４８３
JPN6013049268; Ｂｉｏｃｈｅｍｉｃａｌ ａｎｄ Ｂｉｏｐｈｙｓｉｃａｌ Ｒｅｓｅａｒｃｈ Ｃｏｍｍｕｎｉｃａｔｉｏｎ Ｖｏｌ．２０４，Ｎｏ．２, 1994, ｐ７１０-７１５
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita