薬物の易変性の疎水性修飾により改善された送達

Title:

薬物の易変性の疎水性修飾により改善された送達

Document Type and Number:

Japanese Patent JP2007505039

Kind Code:

A

Abstract:

Described are drug formulations that increase regional delivery of the drugs to cells. Methods for reversibly increasing the hydrophobicity of a drug through hydrolytic ally labile attachment of a hydrophobic moiety and methods for delivering the modified drug to cells is described. Hydrophobic modification increases drug delivery, while lability minimizes entry of the drug into non-target cells.

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Inventors:

Monaghan, Shawn, Dee
Cactus, Vladimir
Bad Car, Vladimir, Gee
Neil, Zain, Sea

Application Number:

JP2006525403A

Publication Date:

March 08, 2007

Filing Date:

August 31, 2004

Export Citation:

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Assignee:

Mirus Bio Corporation

International Classes:

A61K31/282; A61K9/00; A61K31/473; A61K31/58; A61K31/65; A61K31/695; A61K31/704; A61P35/00; A61P43/00; C07F7/10; C07J1/00

Domestic Patent References:

JP2002515883A	2002-05-28
JP2002531543A	2002-09-24

Foreign References:

WO2002087586A1	2002-11-07
CA2472188A1	2003-07-31
WO2000075164A1	2000-12-14

Attorney, Agent or Firm:

Tadahiko Ito
Shinsuke Onuki
Tadashige Ito

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