Title:
医薬品化合物のための改善されたリンカー
Document Type and Number:
Japanese Patent JP4610345
Kind Code:
B2
Abstract:
A new and improved method for extending the half life of pharmaceutical compounds for use in diagnostic imaging or therapy uses a novel linker to attach a diagnostic or therapeutic moiety to a targeting peptide or another diagnostic or therapeutic moiety. The resulting compound may have the general formula M-N—O—P-Q, wherein M is the diagnostic or therapeutic moiety, N—O—P is the linker of the present invention, and Q is the targeting peptide. In another embodiment the compounds may have the formula M-N—O—P-M, wherein M is independently a diagnostic or therapeutic moiety and N—O—P is the linker of the invention. Methods for imaging or treating a patient using the compounds of the invention are also provided. Methods and kits for preparing a diagnostic imaging agent from the compound are further provided. Methods for radiotherapy of a patient using the compounds are further provided, as are methods for preparing a radiotherapeutic agent from the compounds.
Inventors:
Christoph De Jaen
Adrian Nan
Rolf E. Swenson
Adrian Nan
Rolf E. Swenson
Application Number:
JP2004566646A
Publication Date:
January 12, 2011
Filing Date:
December 24, 2003
Export Citation:
Assignee:
BRACCO IMAGING S.P.A.
International Classes:
A61K47/48; A61K38/00; A61K38/04; A61K38/095; A61K38/22; A61K38/27; A61K38/28; A61K51/00; A61K51/04; A61K51/08; A61P3/10; A61P35/00; C07D403/14; C07K7/06; C07K7/08; C07K7/23; C07K14/62
Domestic Patent References:
| JP2002533420A | ||||
| JP3109396A |
Foreign References:
| WO2001064708A1 | ||||
| WO2001076531A1 | ||||
| WO2001009163A1 |
Other References:
J. Pharmacobio-Dyn.,1985年,8,440-447
Chromatographia,2001年,53(9-10),515-518
Chromatographia,2001年,53(9-10),515-518
Attorney, Agent or Firm:
Kyousei Tamura
Minato Saito
Nagatoshi Shinagawa
Minato Saito
Nagatoshi Shinagawa