IMPROVED MANUFACTURE FOR QUINOLINE-3-CARBOXYLIC ACID ANTIBACTERIAL

Title:

IMPROVED MANUFACTURE FOR QUINOLINE-3-CARBOXYLIC ACID ANTIBACTERIAL

Document Type and Number:

Japanese Patent JPS61221174

Kind Code:

A

Abstract:

An improved process for the preparation of 7-substituted amino-1-cyclopropyl-6, 8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids of formula and pharmaceutically acceptable acid addition or base salts thereof, wherein A is a substituted amino group, X is hydrogen or fluorine, and R2 is alkyl of one to three carbon atoms or cycloalkyl of three to six carbon atoms, is described. An alkyl ester precursor is converted via an anhydrous preparation to an alkali metal salt which in a separate step or in situ is displaced and hydrolyzed to the desired product.

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Inventors:

JIYON EMU DOOMAGARA
MERU SHII SHIYUREEDAA

Application Number:

JP6426786A

Publication Date:

October 01, 1986

Filing Date:

March 24, 1986

Export Citation:

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Assignee:

WARNER LAMBERT CO

International Classes:

C07D215/56; C07D401/04; C07D451/04; C07D471/08; C07D487/04; C07D487/08; C07D487/10; (IPC1-7): C07D207/00; C07D215/00; C07D215/56; C07D221/00; C07D401/04; C07D451/04; C07D471/08; C07D487/04

Attorney, Agent or Firm:

Chika Takagi

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