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Title:
IMPROVED METHOD OF ADMINISTERING BETA-HYDROXY-BETA-METHYL BUTYRATE (HMB)
Document Type and Number:
Japanese Patent JP2016026181
Kind Code:
A
Abstract:
PROBLEM TO BE SOLVED: To provide a method for administering β-hydroxy-β-methylbutyric acid (HMB) enabling delivery of HMB to muscle etc. at a more effective timing.SOLUTION: According to the method, a composition that contains 0.5-30 g of HBM-acid as a gel is sublingually administered to be swallowed. The HMB administration method comprises administration of free HMB-acid to a human subject which results in increase in effect of HMB compared with the other methods in which HMB is administered in other forms such as a calcium salt HMB composition. Administration of HMB-acid results in the increased peak level of HMB in plasma compared with administration of a similar dose of a calcium salt HMB composition. Administration of HMB-acid results in a faster time to reach the peak HMB plasma levels in comparison with administration of a similar dosage of a calcium salt HMB composition.SELECTED DRAWING: None

Inventors:
JOHN RATHMACHER
JOHN FULLER
SHAWN BAIER
STEVE NISSEN
NAJI ABUMRAD
Application Number:
JP2015188107A
Publication Date:
February 12, 2016
Filing Date:
September 25, 2015
Export Citation:
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Assignee:
METABOLIC TECHNOLOGIES INC
International Classes:
A61K31/19; A61K9/06; A61P3/00; A61P3/04; A61P3/06; A61P21/00; A61P25/18; A61P37/02
Domestic Patent References:
JP2009155336A2009-07-16
JP2007530542A2007-11-01
JPH04506606A1992-11-19
Foreign References:
US20010008641A12001-07-19
US4992470A1991-02-12
Other References:
NUTRITION & METABOLISM, vol. ６, JPN6014034991, February 2009 (2009-02-01), ISSN: 0003358944
Attorney, Agent or Firm:
Shinjiro Ono
Yasushi Kobayashi
Shigeo Takeuchi
Osamu Yamamoto
Takumi Terachi



 
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