Title:
活性成分の固体分散体を生産するための改良プロセス
Document Type and Number:
Japanese Patent JP5861057
Kind Code:
B2
Abstract:
The present invention relates to a solid dispersion comprising a biologically active ingredient and a matrix-forming agent, wherein the biologically active ingredient comprises ritonavir and the solid dispersion has been obtained by a process which comprises feeding the active ingredient and a matrix-forming agent to an extruder and forming a uniform extrudate, wherein the extruder comprises at least two rotating shafts (2), each of the shafts (2) carrying a plurality of processing elements disposed axially one behind the other, the processing elements defining (i) a feeding and conveying section (A), (ii) at least one mixing section (B), and (iii) a discharging section (E), wherein the processing element(s) defining the mixing section (B) comprise(s) a mixing element (11, 12, 13) that is derived from a screw type element.
Inventors:
Kessler Thomas
Breitenbach Jorg
Schmid Christoph
Degenhardt Matthias
Rosenberg Jorg
Kururu Harald
Berndol Gunther
Breitenbach Jorg
Schmid Christoph
Degenhardt Matthias
Rosenberg Jorg
Kururu Harald
Berndol Gunther
Application Number:
JP2014205061A
Publication Date:
February 16, 2016
Filing Date:
October 03, 2014
Export Citation:
Assignee:
Abbey Deutschland G.M.B.H.
International Classes:
A61K9/20; A61J3/06; A61J3/07; A61K9/48; A61K9/54; A61K47/04; A61K47/10; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61K47/44; B29C48/395; B29C48/405; B29C48/41; B29C48/45; B29C48/455; B29C48/67; B29C48/76
Domestic Patent References:
| JP2005503355A | ||||
| JP2000502300A | ||||
| JP2005533681A | ||||
| JP2001527464A | ||||
| JP2004501679A | ||||
| JP11501050A | ||||
| JP2003011193A | ||||
| JP2002511777A |
Foreign References:
| US20050186427 | ||||
| WO1992018106A1 | ||||
| WO2003077827A1 |
Other References:
著者:James L.White 訳者:酒井 忠基,「訳文:二軸スクリュ押出しーその技術と理論」,訳文発行所:株式会社シグマ出版,1993年,p.204-206
Attorney, Agent or Firm:
Shinei Patent Office