Title:
IMPROVED PRODRUG ACTIVATED WITH ENZYME
Document Type and Number:
Japanese Patent JPH07149667
Kind Code:
A
Abstract:
PURPOSE: To provide a prodrug that is enzymatically clreavable in a significantly lower prodrug molar concentration than that of the state of the art suitable for natural or standard substrate that has been used in the enzyme analyses. CONSTITUTION: A prodrug is provided that is activated by an enzyme having a structure of the formula: S-Z-W (W is a pharmacologically active substance, Z shows a self-decomposable spacer or a bond, and S is a residue that is enzymatically Z-S linkage-cleavable with a double or more reduced Michaelis- Menten constant (Km).
Inventors:
KURAUSU BOSURETSUTO
IERUKU CHIETSUKU
DEIITAA HOFUMAN
ANDOREEA BUAZERA
ROORANTO HOOSU
FURANSOWA TEIIKEN
JIYANNKUROODO FURORAN
MISHIERU AZURE
KUROODO MONERE
JIYANNKUROODO JIYAAKUSHI
JIYANNPIEERU JIESON
MISHIERU KOTSUHO
IERUKU CHIETSUKU
DEIITAA HOFUMAN
ANDOREEA BUAZERA
ROORANTO HOOSU
FURANSOWA TEIIKEN
JIYANNKUROODO FURORAN
MISHIERU AZURE
KUROODO MONERE
JIYANNKUROODO JIYAAKUSHI
JIYANNPIEERU JIESON
MISHIERU KOTSUHO
Application Number:
JP21459794A
Publication Date:
June 13, 1995
Filing Date:
September 08, 1994
Export Citation:
Assignee:
BEHRINGWERKE AG
HOECHST SA LAB
HOECHST SA LAB
International Classes:
A61K31/70; A61K31/7028; A61K31/7034; A61K31/704; C07H15/203; A61K47/48; A61P35/00; A61P43/00; C07H15/244; (IPC1-7): A61K47/48; A61K31/70; C07H15/203; C07H15/244
Attorney, Agent or Firm:
Chika Takagi (2 outside)