Login| Sign Up| Help| Contact|

Patent Searching and Data


Title:
IMPROVED PRODRUG ACTIVATED WITH ENZYME
Document Type and Number:
Japanese Patent JPH07149667
Kind Code:
A
Abstract:
PURPOSE: To provide a prodrug that is enzymatically clreavable in a significantly lower prodrug molar concentration than that of the state of the art suitable for natural or standard substrate that has been used in the enzyme analyses. CONSTITUTION: A prodrug is provided that is activated by an enzyme having a structure of the formula: S-Z-W (W is a pharmacologically active substance, Z shows a self-decomposable spacer or a bond, and S is a residue that is enzymatically Z-S linkage-cleavable with a double or more reduced Michaelis- Menten constant (Km).

Inventors:
KURAUSU BOSURETSUTO
IERUKU CHIETSUKU
DEIITAA HOFUMAN
ANDOREEA BUAZERA
ROORANTO HOOSU
FURANSOWA TEIIKEN
JIYANNKUROODO FURORAN
MISHIERU AZURE
KUROODO MONERE
JIYANNKUROODO JIYAAKUSHI
JIYANNPIEERU JIESON
MISHIERU KOTSUHO
Application Number:
JP21459794A
Publication Date:
June 13, 1995
Filing Date:
September 08, 1994
Export Citation:
Click for automatic bibliography generation   Help
Assignee:
BEHRINGWERKE AG
HOECHST SA LAB
International Classes:
A61K31/70; A61K31/7028; A61K31/7034; A61K31/704; C07H15/203; A61K47/48; A61P35/00; A61P43/00; C07H15/244; (IPC1-7): A61K47/48; A61K31/70; C07H15/203; C07H15/244
Attorney, Agent or Firm:
Chika Takagi (2 outside)



 
Previous Patent: playground

Next Patent: SUBSTANCE FOR DETECTING AMYLOID DEPOSIT