PURPOSE: To obtain the titled compound useful as a psychotropic agent such as an antidepressant, antianxiety agent, anticonvulsant, etc. by a short process in high yield, by reacting an aminobenzophenonimine derivative with a glycine ester, treating the reaction product with an acid.
CONSTITUTION: A compound shown by the formula I (R is H, or alkyl; X and Y are H, or halogen) is reacted with a glycine ester (preferably used as a salt of mineral acid such as hydrochloride, etc.) in a solvent such as methanol, etc. at about the boiling point of the solvent under heating, to give a compound shown by the formula II. The compound is then subjected to ring closure with an acid such as trifluoroacetic acid, methanesulfonic acid, etc. at 20W150°C, preferably at 50W100°C, to give the desired substance shown by the formula III.
SAKURA KAZUYUKI
SUGASAWA TSUTOMU
| JP43014689A | ||||
| JPS47814A |