Title:
改良Ｎ４キレーターコンジュゲート
Document Type and Number:
Japanese Patent JP5557425
Kind Code:
B2
Abstract:
The present invention provides tetra-amine chelator conjugates with biological targeting moieties, linked via a linker group and technetium complexes thereof as radiopharmaceuticals. The linker group is such that the chelator is mono-functionalized at the bridgehead position and provides both flexibility and a lack or aryl groups, to minimize lipophilicity and steric hulk. Protected versions of the chelators are provided which permit conjugation with a wide range of targeting molecules without interfering reactions with the amine nitrogens of the tetra-amine chelator. Syntheses of the functionalised chelators are described, together with bifunctional chelate precursors. Radiopharmaceutical compositions comprising the technetium metal complexes of the invention are described, together with non-radioactive kits for the preparation of such radiopharmaceuticals.
Inventors:
A story, Anthony Eamonn
ワズワース, Harry
Powell, Nigel Anthony
Duncan Son, Philip
ワズワース, Harry
Powell, Nigel Anthony
Duncan Son, Philip
Application Number:
JP2007522011A
Publication Date:
July 23, 2014
Filing Date:
July 19, 2005
Export Citation:
Assignee:
GE health care Limited
International Classes:
C07C233/05; A61K51/00; A61K51/04; A61K51/08; A61P43/00; C07B59/00; C07C237/06; C07C271/20; C07C271/22; C07F13/00; G01T1/161
Attorney, Agent or Firm:
Satoshi Arakawa
Hiroshi Ogura
Toshihisa Kurokawa
Hiroshi Ogura
Toshihisa Kurokawa