Title:
多能性幹細胞による胎児発育不全に伴う脳障害の改善及び治療
Document Type and Number:
Japanese Patent JP7255805
Kind Code:
B2
Abstract:
The purpose of the present invention is to provide a novel medical application of pluripotent stem cells (muse cells) in regeneration medicine. The present invention provides a cell preparation and a pharmaceutical composition which are for amelioration and treatment of brain disorders resulting from fetal growth retardation, such as abnormal motor quality or abnormal neurological development, and which contain SSEA-3 positive pluripotent stem cells isolated from a mesenchymal tissue from a live body or cultured mesenchymal cells. It is assumed that this cell preparation is based on a mechanism where muse cells that are administered to objects having the disorders are engrafted on an impaired brain tissue, thereby ameliorating or treating the disorders.
Inventors:
Yoshiro Sato
Yuma Kitase
Shinobu Shimizu
Mizuno Masaaki
Masahiro Hayakawa
Mari Dezawa
Masahiro Tsuji
Yuma Kitase
Shinobu Shimizu
Mizuno Masaaki
Masahiro Hayakawa
Mari Dezawa
Masahiro Tsuji
Application Number:
JP2019525672A
Publication Date:
April 11, 2023
Filing Date:
June 20, 2018
Export Citation:
Assignee:
Tokai National University Organization
Tohoku University
National Cardiovascular Research Center
Life Science Institute Inc.
Tohoku University
National Cardiovascular Research Center
Life Science Institute Inc.
International Classes:
A61K35/545; A61P25/00; A61P25/14; A61P25/28
Domestic Patent References:
| JP2015159895A |
Other References:
佐藤義朗,周産期疾患に対するMuse細胞を用いた新規治療法の開発,再生医療 第16回日本再生医療学会総会プログラム・抄録,2017年02月01日,Vol.16, Suppl,p.179[SY-17-4],ISSN 1347-7919
鈴木俊彦ほか,新生児低酸素性虚血性脳症に対するMultilineage-differentiating stress enduring cellsを用いた幹細胞療法,日本周産期・新生児医学会雑誌,2016年06月,第52巻, 第2号,p.608,ISSN 1348-964X
周産期医学,2010年,Vol.40, No.2,pp.205-208,ISSN 0386-9881
周産期医学,2013年,Vol.43, No.2,pp.208-212,ISSN 0386-9881
杉山裕一朗、外10名,新生児低酸素性虚血性脳症モデルラットにおける間葉系幹細胞療法の検討,再生医療、第15回日本再生医療学会総会プログラム・抄録,2016年02月01日,Vol.15、Suppl,p.261,ISSN 1347-7919
Dev. Neurosci.,2015年,Vol.37,pp.95-104,ISSN 0378-5866
Trends in Glycoscience and Glycotechnology,2009年,Vol. 21, No. 120,pp. 207-218
Trends in Glycoscience and Glycotechnology,2009年,Vol. 21, No. 120,pp. 197-206
鈴木俊彦ほか,新生児低酸素性虚血性脳症に対するMultilineage-differentiating stress enduring cellsを用いた幹細胞療法,日本周産期・新生児医学会雑誌,2016年06月,第52巻, 第2号,p.608,ISSN 1348-964X
周産期医学,2010年,Vol.40, No.2,pp.205-208,ISSN 0386-9881
周産期医学,2013年,Vol.43, No.2,pp.208-212,ISSN 0386-9881
杉山裕一朗、外10名,新生児低酸素性虚血性脳症モデルラットにおける間葉系幹細胞療法の検討,再生医療、第15回日本再生医療学会総会プログラム・抄録,2016年02月01日,Vol.15、Suppl,p.261,ISSN 1347-7919
Dev. Neurosci.,2015年,Vol.37,pp.95-104,ISSN 0378-5866
Trends in Glycoscience and Glycotechnology,2009年,Vol. 21, No. 120,pp. 207-218
Trends in Glycoscience and Glycotechnology,2009年,Vol. 21, No. 120,pp. 197-206
Attorney, Agent or Firm:
Aoki Atsushi
Shinji Mihashi
Youichi Watanabe
Nakajima Masaru
Ryotaro Takei
Shinji Mihashi
Youichi Watanabe
Nakajima Masaru
Ryotaro Takei
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